Mouse Transmembrane 4 L6 Family Member 1 (TM4SF1) ELISA Kit
715€ (96 tests)
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935106861
info@markelab.com
name
Mouse Transmembrane 4 L6 Family Member 1 (TM4SF1) ELISA Kit
category
ELISA Kits
provider
Abbexa
reference
abx548539
tested applications
ELISA
Description
Mouse Transmembrane 4 L6 Family Member 1 (TM4SF1) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Mouse Transmembrane 4 L6 Family Member 1 concentrations in tissue homogenates, cell lysates and other biological fluids.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | ELISA Kits |
| Immunogen Target | Transmembrane 4 L6 Family Member 1 (TM4SF1) |
| Reactivity | Mouse |
| Detection Method | Colorimetric |
| Assay Data | Quantitative |
| Assay Type | Sandwich |
| Test Range | 0.156 ng/ml - 10 ng/ml |
| Sensitivity | < 0.07 ng/ml |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 96 tests |
| Form | Lyophilized |
| Tested Applications | ELISA |
| Sample Type | Tissue homogenates, cell lysates and other biological fluids. |
| Availability | Shipped within 5-15 working days. The validity for this kit is 6 months. |
| Storage | Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| UniProt ID | Q64302 |
| Gene ID | 17112 |
| Alias | H-L6,L6,M3S1,TAAL6,Tumor-associated antigen L6 |
| Background | Elisa kits for TM4SF1 |
| Status | RUO |
| Note | Validity: The validity for this kit is 6 months. This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. |
Descripción
Transmembrane 4 L6 family member 1 (TM4SF1) is a cell surface glycoprotein that belongs to the tetraspanin superfamily, characterized by four transmembrane domains and involvement in cell signaling, adhesion, migration, and proliferation. It is highly expressed in various cancers, including breast, lung, pancreatic, and prostate cancers, and is associated with tumor progression, metastasis, and poor prognosis. TM4SF1 plays a critical role in endothelial cell function and angiogenesis, influencing vascular remodeling and contributing to tumor vascularization. It interacts with integrins and growth factor receptors, modulating signaling pathways such as PI3K/Akt and MAPK, which are critical for cell survival and migration. Its overexpression enhances the invasive potential of cancer cells and their ability to form metastatic colonies. TM4SF1 is also involved in exosome production and intercellular communication, facilitating the transfer of oncogenic signals within the tumor microenvironment. Its expression is tightly regulated by transcriptional and post-transcriptional mechanisms, including microRNAs, which further modulate its function in both physiological and pathological conditions. As a cancer-associated antigen with limited expression in normal tissues, TM4SF1 is being explored as a potential therapeutic target, with antibody-drug conjugates and inhibitors showing promise in preclinical studies.
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