TM4SF1 - Transmembrane 4 L6 family member 1 | Elisa - Clia - Antibody - Protein
Family main features
Background
Transmembrane 4 L6 family member 1 (TM4SF1) is a protein encoded by the TM4SF1 gene. This protein belongs to the tetraspanin superfamily, also known as the transmembrane 4 superfamily, characterized by four transmembrane domains. TM4SF1 is expressed in a variety of tissues but is notably upregulated in certain cancerous tissues, implicating it in tumor progression and metastasis. Its expression has been associated with cell proliferation, motility, and angiogenesis, making it a potential target for cancer therapy.
Protein Structure
TM4SF1 is a membrane protein that spans the cell membrane four times, forming two extracellular loops, one small and one large, and having cytoplasmic N- and C-termini. The key structural features include:
- Four Transmembrane Domains: These hydrophobic regions anchor the protein within the cell membrane.
- Two Extracellular Loops: The larger extracellular loop often plays a role in protein-protein interactions, critical for signaling pathways.
- Intracellular N- and C-Termini: These regions can interact with intracellular signaling molecules and cytoskeletal elements.
Classification and Subtypes
TM4SF1 is a member of the tetraspanin family, which includes several other proteins involved in cell adhesion, motility, and signal transduction. These proteins share common structural features but have diverse functions and tissue distribution.
Function and Biological Significance
TM4SF1 is involved in various cellular processes:
- Cell Proliferation and Migration: It promotes cell growth and movement, essential in wound healing and cancer metastasis.
- Angiogenesis: TM4SF1 supports the formation of new blood vessels, a crucial process in both normal physiology and tumor growth.
- Signal Transduction: It interacts with other cell surface receptors and intracellular signaling molecules to modulate cell behavior.
Clinical Issues
Dysregulation or overexpression of TM4SF1 has been linked to several clinical conditions, particularly in oncology:
- Cancer: High levels of TM4SF1 are found in many cancers, including breast, prostate, and pancreatic cancers. Its expression correlates with poor prognosis and increased metastatic potential.
- Therapeutic Target: Due to its role in tumor progression, TM4SF1 is being explored as a therapeutic target. Inhibiting TM4SF1 function could potentially reduce tumor growth and metastasis.
- Biomarker: TM4SF1 might serve as a biomarker for certain cancers, aiding in diagnosis and prognosis.
Summary
Transmembrane 4 L6 family member 1 (TM4SF1) is a tetraspanin protein involved in critical cellular processes such as proliferation, migration, and angiogenesis. Its significant role in tumor progression and metastasis makes it a promising target for cancer therapy. Understanding the structure and function of TM4SF1 is crucial for developing new therapeutic strategies and improving cancer
TM4SF1 Recommended name:
Transmembrane 4 L6 family member 1 (TM4SF1)
Aliases for TM4SF1
H-L6,L6,M3S1,TAAL6,Tumor-associated antigen L6
En la tabla siguiente se muestra una comparativa de todos los reactivos disponibles en nuestro catálogo (Primary Antibodies, ELISA Kits) relacionados con TM4SF1 - Transmembrane 4 L6 family member 1
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Esta página contiene 11 reactivos de las marcas (Abbexa, FineTest) que se corresponden con tu busqueda
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immunoassays
provider | Code | reference | name | reactivity | sample type | assay type | test range | sensitivity | price | size 1 | uniprot id | status |
---|---|---|---|---|---|---|---|---|---|---|---|---|
Abbexa | TM4SF1 | abx548538 | Human Transmembrane 4 L6 Family Member 1 (TM4SF1) ELISA Kit | Human | Tissue homogenates, cell lysates and other biological fluids. | Sandwich | 0.312 ng/ml - 20 ng/ml | < 0.13 ng/ml | 715 | 96 tests | P30408 | RUO |
Abbexa | TM4SF1 | abx548539 | Mouse Transmembrane 4 L6 Family Member 1 (TM4SF1) ELISA Kit | Mouse | Tissue homogenates, cell lysates and other biological fluids. | Sandwich | 0.156 ng/ml - 10 ng/ml | < 0.07 ng/ml | 715 | 96 tests | Q64302 | RUO |
Primary Antibodies
provider | Code | reference | name | reactivity | clonality | host | immunogen target | isotype | conjugation | tested applications | price | size 1 | uniprot id | status |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Abbexa | TM4SF1 | abx349966 | Transmembrane 4 L6 Family Member 1 (TM4SF1) Antibody | Human | Monoclonal | Human | Transmembrane 4 L6 Family Member 1 (TM4SF1) | IgG1 | Unconjugated | ELISA | 299 | 50 µl | P30408 | RUO |
Abbexa | TM4SF1 | abx305557 | TM4SF1 Antibody (FITC) | Human | Polyclonal | Rabbit | TM4SF1 | IgG | FITC | 169 | 20 µg | P30408 | RUO | |
Abbexa | TM4SF1 | abx305558 | TM4SF1 Antibody (Biotin) | Human | Polyclonal | Rabbit | TM4SF1 | IgG | Biotin | ELISA | 169 | 20 µg | P30408 | RUO |
Abbexa | TM4SF1 | abx301961 | Transmembrane 4 L Six Family Member 1 (TM4SF1) Antibody | Human | Polyclonal | Rabbit | Transmembrane 4 L Six Family Member 1 (TM4SF1) | IgG | Unconjugated | ELISA, IHC, IF/ICC | 169 | 20 µg | P30408 | RUO |
Abbexa | TM4SF1 | abx305556 | TM4SF1 Antibody (HRP) | Human | Polyclonal | Rabbit | TM4SF1 | IgG | HRP | ELISA | 169 | 20 µg | P30408 | RUO |
Abbexa | TM4SF1 | abx375202 | Transmembrane 4 L Six Family Member 1 (TM4SF1) Antibody | Human | Polyclonal | Rabbit | Transmembrane 4 L Six Family Member 1 (TM4SF1) | Unconjugated | ELISA, IHC | 351 | 100 µg | P30408 | RUO | |
Abbexa | TM4SF1 | abx212798 | Transmembrane 4 L Six Family Member 1 (TM4SF1) Antibody | Human | Polyclonal | Rabbit | Transmembrane 4 L Six Family Member 1 (TM4SF1) | IgG | Unconjugated | ELISA, IHC | 260 | 50 µl | P30408 | RUO |
Abbexa | TM4SF1 | abx212797 | Transmembrane 4 L Six Family Member 1 (TM4SF1) Antibody | Human | Polyclonal | Rabbit | Transmembrane 4 L Six Family Member 1 (TM4SF1) | IgG | Unconjugated | ELISA, IHC | 260 | 50 µl | P30408 | RUO |
Abbexa | TM4SF1 | abx325220 | Transmembrane 4 L Six Family Member 1 (TM4SF1) Antibody | Human | Polyclonal | Rabbit | Transmembrane 4 L Six Family Member 1 (TM4SF1) | IgG | Unconjugated | ELISA, IHC | 221 | 50 µg | P30408 | RUO |
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