Mouse Transcription factor E2F8 (E2F8) ELISA Kit
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935106861
info@markelab.com
Precio
715€ (96 tests)
Elisa kits for E2F8
proveedor
Abbexareference
abx520223Tested Applications
ELISAreactivity
Mousestatus
RUOclonality
Descripción
Mouse Transcription factor E2F8 (E2F8) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Mouse Transcription factor E2F8 concentrations in tissue homogenates, cell lysates and other biological fluids.
Background
E2F8 is another atypical member of the E2F family that functions as a transcriptional repressor, particularly during the late stages of the cell cycle. Like E2F7, E2F8 contains two DNA-binding domains but lacks a transactivation domain, allowing it to bind and repress E2F target genes involved in cell proliferation, DNA replication, and mitosis. E2F8 is upregulated during the G2/M phase and works in conjunction with E2F7 to suppress aberrant cell cycle progression and regulate genomic stability. E2F8 is critical for embryonic development, angiogenesis, and placental formation, where it regulates the proliferation of endothelial cells and trophoblasts. Dysregulation of E2F8 has been linked to cancer progression, as its overexpression promotes tumor growth, metastasis, and chemoresistance. Knockout models reveal defects in placental vascularization, embryonic lethality, and impaired cell cycle regulation, emphasizing its importance in cell cycle control, development, and cancer biology.
Características del producto
category
ELISA Kits
immunogen target
Transcription factor E2F8 (E2F8)
reactivity
Mouse
test range
0.156 ng/ml - 10 ng/ml
assay data
Quantitative
form
Lyophilized
detection method
Colorimetric
sample type
Tissue homogenates, cell lysates and other biological fluids.
size 1
96 tests
alias
E2F-8
storage
Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual.
or code
E2F8
dry ice
No
uniprot id
note
This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.
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