E2F Transcription Factor 8 (E2F8) Antibody
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Description
E2F8 Antibody is a Rabbit Polyclonal antibody against E2F8. This gene encodes a member of a family of transcription factors which regulate the expression of genes required for progression through the cell cycle. The encoded protein regulates progression from G1 to S phase by ensuring the nucleus divides at the proper time. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jan 2012].
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Product specifications
| Category | Primary Antibodies |
| Immunogen Target | E2F Transcription Factor 8 (E2F8) |
| Host | Rabbit |
| Reactivity | Human, Mouse |
| Recommended Dilution | ELISA: 1 µg/ml, WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified by affinity chromatography. |
| Size 1 | 20 µl |
| Size 2 | 100 µl |
| Size 3 | 2 × 100 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB |
| Buffer | PBS, pH 7.3, containing 0.09% sodium azide, 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | A0AVK6 |
| Gene ID | 79733 |
| NCBI Accession | NP_078956.2 |
| Alias | E2F-8 |
| Background | Antibody anti-E2F8 |
| Status | RUO |
| Note | Concentration: > 0.2 mg/ml - |
Descripción
E2F8 is another atypical member of the E2F family that functions as a transcriptional repressor, particularly during the late stages of the cell cycle. Like E2F7, E2F8 contains two DNA-binding domains but lacks a transactivation domain, allowing it to bind and repress E2F target genes involved in cell proliferation, DNA replication, and mitosis. E2F8 is upregulated during the G2/M phase and works in conjunction with E2F7 to suppress aberrant cell cycle progression and regulate genomic stability. E2F8 is critical for embryonic development, angiogenesis, and placental formation, where it regulates the proliferation of endothelial cells and trophoblasts. Dysregulation of E2F8 has been linked to cancer progression, as its overexpression promotes tumor growth, metastasis, and chemoresistance. Knockout models reveal defects in placental vascularization, embryonic lethality, and impaired cell cycle regulation, emphasizing its importance in cell cycle control, development, and cancer biology.
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