Mouse E2F Transcription Factor 7 (E2F7) ELISA Kit
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935106861
info@markelab.com
Precio
715€ (96 tests)
Elisa kits for E2F7
proveedor
Abbexareference
abx520219Tested Applications
ELISAreactivity
Mousestatus
RUOclonality
Descripción
Mouse Transcription factor E2F7 (E2F7) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Mouse Transcription factor E2F7 concentrations in tissue homogenates, cell lysates and other biological fluids.
Background
E2F7 is an atypical E2F transcription factor that functions as a repressor of E2F target genes, particularly those involved in DNA replication and cell cycle progression. Unlike classical E2Fs, E2F7 contains two DNA-binding domains but lacks a transactivation domain, enabling it to directly bind and repress target promoters without the involvement of RB proteins. E2F7 is upregulated during the G2/M phase and acts as a negative feedback regulator to suppress E2F-driven proliferation. It plays a key role in cellular stress responses, where it regulates genes involved in DNA damage repair, such as p53 target genes, to maintain genomic stability. Dysregulation of E2F7 contributes to tumorigenesis by disrupting cell cycle checkpoints and DNA damage responses. Knockout studies show increased sensitivity to DNA damage, defective cell cycle arrest, and aberrant proliferation, underscoring E2F7’s role in genomic maintenance, stress response, and tumor suppression.
Características del producto
category
ELISA Kits
immunogen target
Transcription factor E2F7 (E2F7)
reactivity
Mouse
test range
78 pg/ml - 5000 pg/ml
sensitivity
< 29.5 pg/ml
assay type
Sandwich
assay data
Quantitative
form
Lyophilized
detection method
Colorimetric
sample type
Tissue homogenates, cell lysates and other biological fluids.
size 1
96 tests
alias
E2F-7
storage
Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual.
or code
E2F7
dry ice
No
uniprot id
note
This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.
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