Mouse Transcription factor E2F3 (E2F3) ELISA Kit
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935106861
info@markelab.com
Precio
715€ (96 tests)
Elisa kits for E2F3
proveedor
Abbexareference
abx520208Tested Applications
ELISAreactivity
Mousestatus
RUOclonality
Descripción
Mouse Transcription factor E2F3 (E2F3) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Mouse Transcription factor E2F3 concentrations in tissue homogenates, cell lysates and other biological fluids.
Background
E2F3 is a critical transcription factor involved in cell cycle regulation, particularly during the G1-to-S phase transition. It promotes the expression of genes essential for DNA synthesis, cell proliferation, and mitotic progression, such as cyclin E and CDC6. E2F3 exists in two isoforms, E2F3a and E2F3b, which have distinct functions: E2F3a primarily drives cell proliferation, while E2F3b has roles in transcriptional repression and cellular quiescence. Dysregulation of E2F3 is associated with cancers such as bladder, lung, and prostate cancer, where its overexpression leads to uncontrolled proliferation and genomic instability. E2F3 is negatively regulated by the retinoblastoma protein (RB), and mutations in the RB pathway often result in E2F3 hyperactivity. Knockout studies demonstrate impaired cell proliferation, reduced embryonic development, and defects in organogenesis, highlighting E2F3's role in cell growth, differentiation, and tumor progression.
Características del producto
category
ELISA Kits
immunogen target
Transcription factor E2F3 (E2F3)
reactivity
Mouse
test range
0.156 ng/ml - 10 ng/ml
assay data
Quantitative
form
Lyophilized
detection method
Colorimetric
sample type
Tissue homogenates, cell lysates and other biological fluids.
size 1
96 tests
alias
E2F-3,KIAA0075
storage
Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual.
or code
E2F3
dry ice
No
uniprot id
note
This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.
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