Mouse Tissue Factor Pathway Inhibitor 2 (TFPI2) Protein
1235€ (100 µg)
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935106861
info@markelab.com
name
Mouse Tissue Factor Pathway Inhibitor 2 (TFPI2) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx692198
tested applications
SDS-PAGE
Description
Mouse TFPI2 Protein is a recombinant protein from Mouse produced in HEK293 Cells. A DNA sequence encoding the mouse TFPI2 (O35536) (Met 1-Lys 211) was expressed, with a C-terminal polyhistidine tag.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | TFPI2 |
| Host | HEK293 cells |
| Origin | Mouse |
| Observed MW | Molecular Weight: 22.8 kDa Sequence Fragment: Met1-Lys211 Tag: C-terminal His tag Validity: The validity for this protein is 12 months. |
| Expression | Recombinant |
| Purity | > 95% (SDS-PAGE) |
| Size 1 | 100 µg |
| Form | |
| Tested Applications | SDS-PAGE |
| Buffer | Lyophilized from sterile 25mM Tris, 150mM NaCl, pH 7.4. |
| Availability | Shipped within 5-15 working days. |
| Storage | Aliquot and store at -20°C or -80°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | O35536 |
| Alias | PP5,REF1,TFPI-2,Placental protein 5 |
| Background | Protein TFPI2 |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
Tissue Factor Pathway Inhibitor 2 (TFPI2), another Kunitz-type inhibitor, is structurally similar to TFPI but exhibits distinct functions, primarily inhibiting plasmin and matrix metalloproteinases (MMPs). TFPI2 plays a critical role in modulating extracellular matrix degradation, cell migration, and angiogenesis, influencing processes like wound healing, tissue remodeling, and tumor progression. Unlike TFPI, TFPI2 is broadly expressed in various tissues and is frequently downregulated in cancers, where its loss contributes to tumor invasion, metastasis, and angiogenesis. Its epigenetic silencing through promoter hypermethylation is a hallmark in several malignancies, highlighting its potential as a tumor suppressor and biomarker for cancer diagnosis and prognosis.
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