Mouse Tissue Factor Pathway Inhibitor 2 (TFPI2) Protein
1118€ (50 µg)
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935106861
info@markelab.com
name
Mouse Tissue Factor Pathway Inhibitor 2 (TFPI2) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx691064
tested applications
SDS-PAGE
Description
Tissue Factor Pathway Inhibitor 2 (TFPI2) protein is a recombinant Mouse protein expressed in HEK293 cells.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | Tissue Factor Pathway Inhibitor 2 (TFPI2) |
| Host | HEK293 cells |
| Assay Type | Activity: Not tested Sequence Fragment: Met1-Lys211 Tag: C-terminal Fc tag |
| Origin | Mouse |
| Observed MW | 48.4 kDa |
| Expression | Recombinant |
| Purity | > 83% (SDS-PAGE) |
| Size 1 | 50 µg |
| Form | Lyophilized |
| Tested Applications | SDS-PAGE |
| Buffer | Prior to lyophilization: Sterile PBS, pH 7.4. |
| Availability | Shipped within 5-15 working days. |
| Storage | Storage: Store lyophilized between -20 °C and -80°C. Stability: Stable when stored reconstituted at 2-8°C for up to 1 week. Reconstituted aliquots are stable at -20°C for up to 3 months. Shelf Life: 12 months. |
| Dry Ice | No |
| UniProt ID | O35536 |
| Alias | PP5,REF1,TFPI-2,Placental protein 5 |
| Background | Protein TFPI2 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. Endotoxin Level: < 1.0 EU per µg (LAL method). |
Descripción
Tissue Factor Pathway Inhibitor 2 (TFPI2), another Kunitz-type inhibitor, is structurally similar to TFPI but exhibits distinct functions, primarily inhibiting plasmin and matrix metalloproteinases (MMPs). TFPI2 plays a critical role in modulating extracellular matrix degradation, cell migration, and angiogenesis, influencing processes like wound healing, tissue remodeling, and tumor progression. Unlike TFPI, TFPI2 is broadly expressed in various tissues and is frequently downregulated in cancers, where its loss contributes to tumor invasion, metastasis, and angiogenesis. Its epigenetic silencing through promoter hypermethylation is a hallmark in several malignancies, highlighting its potential as a tumor suppressor and biomarker for cancer diagnosis and prognosis.
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