Mouse Sphingosine 1 Phosphate Receptor 4 (S1PR4) ELISA Kit

Este producto es parte de S1PR - Sphingosine 1 Phosphate Receptor
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715€ (96 tests)

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935106861
info@markelab.com
name
Mouse Sphingosine 1 Phosphate Receptor 4 (S1PR4) ELISA Kit
category
ELISA Kits
provider
Abbexa
reference
abx258018
tested applications
ELISA

Description

Mouse Sphingosine 1 Phosphate Receptor 4 (S1PR4) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Mouse Sphingosine 1 Phosphate Receptor 4 concentrations in tissue homogenates, cell lysates and other biological fluids.

Documents del producto

Instrucciones
Data sheet
Descargar

Product specifications

Category
ELISA Kits
Immunogen Target
Sphingosine 1 Phosphate Receptor 4 (S1PR4)
Reactivity
Mouse
Detection Method
Colorimetric
Assay Data
Quantitative
Assay Type
Sandwich
Test Range
78 pg/ml - 5000 pg/ml
Sensitivity
< 30 pg/ml
Recommended Dilution
Optimal dilutions/concentrations should be determined by the end user.
Size 1
96 tests
Size 2
5 × 96 tests
Size 3
10 × 96 tests
Form
Lyophilized
Tested Applications
ELISA
Sample Type
Tissue homogenates, cell lysates and other biological fluids.
Availability
Shipped within 5-7 working days. The validity for this kit is at least 6 months. Up to 12 months validity can be provided on request.
Storage
Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual.
Dry Ice
No
Alias
S1PR4,EDG6,LPC1,S1P4,SLP4,endothelial differentiation G protein-coupled receptor 6
Background
Elisa kits for S1PR4
Status
RUO
Note
Validity: The validity for this kit is at least 6 months. Up to 12 months validity can be provided on request.

This product is for research use only.   The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments.   Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.

Descripción

S1PR4 is a G protein-coupled receptor for sphingosine-1-phosphate (S1P), primarily expressed in hematopoietic cells, including lymphocytes, dendritic cells, and natural killer (NK) cells. S1PR4 couples to Gi and G12/13 proteins, regulating pathways like PI3K/Akt and Rho/ROCK, which control cell migration, immune responses, and cytoskeletal reorganization. S1PR4 plays a critical role in immune cell trafficking, influencing lymphocyte egress from lymphoid tissues and modulating inflammatory responses. It is involved in regulating dendritic cell maturation and T-cell function, positioning it as a key player in adaptive immunity. Dysregulation of S1PR4 is associated with autoimmune diseases, inflammatory disorders, and hematological malignancies. In cancer, S1PR4 has been linked to tumor progression and immune evasion, particularly in leukemia and lymphoma. S1PR4 antagonists are being explored for therapeutic use in autoimmune diseases and cancers by modulating immune cell function and migration, highlighting its importance in immune regulation.

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