Mouse SH2 domain-containing protein 1A (SH2D1A) ELISA Kit
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935106861
info@markelab.com
Precio
715€ (96 tests)
Elisa kits for SH2D1A
proveedor
Abbexareference
abx545628Tested Applications
ELISAreactivity
Mousestatus
RUOclonality
Descripción
Mouse SH2 domain-containing protein 1A (SH2D1A) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Mouse SH2 domain-containing protein 1A concentrations in tissue homogenates, cell lysates and other biological fluids.
Background
SH2D1A, also known as SAP (SLAM-associated protein), is an SH2 domain-containing adaptor protein that regulates signaling pathways downstream of SLAM (Signaling Lymphocyte Activation Molecule) family receptors. It is predominantly expressed in T cells, NK cells, and other immune cells, where it plays a crucial role in immune cell activation, cytotoxicity, and cytokine production. SH2D1A binds to the cytoplasmic tails of SLAM receptors, modulating T-cell receptor (TCR) signaling, NK cell activation, and germinal center formation. Mutations or deletions in SH2D1A cause X-linked lymphoproliferative syndrome (XLP), a severe immunodeficiency characterized by uncontrolled lymphocyte proliferation, impaired antibody responses, and susceptibility to Epstein-Barr virus (EBV) infections. SH2D1A also regulates immune synapse formation and T-cell-B-cell interactions, ensuring proper immune homeostasis. Knockout studies reveal defects in immune cell activation, abnormal germinal center development, and impaired antiviral responses, underscoring its essential role in immune regulation.
Características del producto
category
ELISA Kits
immunogen target
SH2 domain-containing protein 1A (SH2D1A)
reactivity
Mouse
test range
0.156 ng/ml - 10 ng/ml
assay data
Quantitative
form
Lyophilized
detection method
Colorimetric
sample type
Tissue homogenates, cell lysates and other biological fluids.
size 1
96 tests
alias
SH2D1A,DSHP, EBVS, IMD5, LYP, MTCP1, SAP, SAP/XLP, XLPD, XLPD1, SH2 domain containing 1A,SLAM associated protein
storage
Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual.
or code
SH2D1A
dry ice
No
uniprot id
note
This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.
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