Mouse Ragulator complex protein LAMTOR4 (LAMTOR4) ELISA Kit
715€ (96 tests)
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name
Mouse Ragulator complex protein LAMTOR4 (LAMTOR4) ELISA Kit
category
ELISA Kits
provider
Abbexa
reference
abx531707
tested applications
ELISA
Description
Mouse Ragulator complex protein LAMTOR4 (LAMTOR4) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Mouse Ragulator complex protein LAMTOR4 concentrations in tissue homogenates, cell lysates and other biological fluids.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | ELISA Kits |
| Immunogen Target | Ragulator complex protein LAMTOR4 (LAMTOR4) |
| Reactivity | Mouse |
| Detection Method | Colorimetric |
| Assay Data | Quantitative |
| Test Range | 0.156 ng/ml - 10 ng/ml |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 96 tests |
| Form | Lyophilized |
| Tested Applications | ELISA |
| Sample Type | Tissue homogenates, cell lysates and other biological fluids. |
| Availability | Shipped within 5-15 working days. The validity for this kit is 6 months. |
| Storage | Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| UniProt ID | Q8CF66 |
| Gene ID | 66096 |
| Alias | C7orf59,late endosomal/lysosomal adaptor, MAPK and MTOR activator 4 |
| Background | Elisa kits for LAMTOR4 |
| Status | RUO |
| Note | Validity: The validity for this kit is 6 months. This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. |
Descripción
Ragulator complex protein LAMTOR4 is an essential component of the Ragulator complex that interacts with Rag GTPases on the lysosomal membrane to activate mTORC1 signaling in response to amino acid availability LAMTOR4 functions as a scaffold within the complex, enabling mTORC1 to sense nutrient sufficiency and regulate anabolic and catabolic processes such as protein synthesis, autophagy, and cellular metabolism Loss of LAMTOR4 disrupts mTORC1 activation, leading to impaired cell growth, energy metabolism, and lysosomal function Studies indicate that LAMTOR4 is critical for immune cell activation, particularly in T-cell and macrophage responses, where mTOR signaling governs cellular proliferation and differentiation Dysregulation of LAMTOR4 has been linked to neurodegenerative diseases, cancers, and metabolic disorders, as impaired lysosome-mTORC1 communication disrupts cellular homeostasis and stress responses Its role in lysosomal positioning and signaling highlights its importance as a central regulator of nutrient sensing and cellular growth pathways
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