Human LAMTOR4 Protein

Product specifications

Proteins and Peptides

LAMTOR4

E. coli

Human

Unconjugated

Concentration: 0.25 mg/ml
Sequence Fragment: 1-99 AA + tag (23 AA)
Tag: N-terminal His tag

Recombinant

> 85% (SDS-PAGE)

Purified by proprietary chromatographic techniques.

2 µg

10 µg

100 µg

Liquid 

SDS-PAGE

20 mM Tris-HCl buffer, pH 8.0, 0.15 M NaCl, 10% glycerol and 1 mM DTT.

Shipped within 5-10 working days.

Store at 4 °C if the entire vial will be used within 4 weeks. Store at -20 °C for long term storage. For long term storage, it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid repeated freeze/thaw cycles.

No

Q0VGL1

C7orf59,late endosomal/lysosomal adaptor, MAPK and MTOR activator 4

Protein LAMTOR4

RUO

This product is for research use only.   Not for human consumption, cosmetic, therapeutic or diagnostic use.

Descripción

Ragulator complex protein LAMTOR4 is an essential component of the Ragulator complex that interacts with Rag GTPases on the lysosomal membrane to activate mTORC1 signaling in response to amino acid availability LAMTOR4 functions as a scaffold within the complex, enabling mTORC1 to sense nutrient sufficiency and regulate anabolic and catabolic processes such as protein synthesis, autophagy, and cellular metabolism Loss of LAMTOR4 disrupts mTORC1 activation, leading to impaired cell growth, energy metabolism, and lysosomal function Studies indicate that LAMTOR4 is critical for immune cell activation, particularly in T-cell and macrophage responses, where mTOR signaling governs cellular proliferation and differentiation Dysregulation of LAMTOR4 has been linked to neurodegenerative diseases, cancers, and metabolic disorders, as impaired lysosome-mTORC1 communication disrupts cellular homeostasis and stress responses Its role in lysosomal positioning and signaling highlights its importance as a central regulator of nutrient sensing and cellular growth pathways

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