Mouse Protein Tyrosine Phosphatase Receptor Type H (PTPRH) Protein

Este producto es parte de PTPR - protein tyrosine phosphatase receptor type
Product Graph
234€ (10 µg)

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935106861
info@markelab.com
name
Mouse Protein Tyrosine Phosphatase Receptor Type H (PTPRH) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx167995
tested applications
WB, SDS-PAGE

Description

Tyrosine Phosphatase Receptor Type H Protein is a recombinant Mouse protein expressed in E. coli.

Documents del producto

Instrucciones
Data sheet
Descargar

Product specifications

Category
Proteins and Peptides
Immunogen Target
Protein Tyrosine Phosphatase Receptor Type H (PTPRH)
Host
E. coli
Origin
Mouse
Conjugation
Unconjugated
Observed MW
Molecular Weight: Calculated MW: 29.7 kDa

Concentration: Prior to lyophilization: 200 µg/ml

Sequence Fragment: Gln685-Ser909

Tag: N-terminal His tag
Expression
Recombinant
Purity
> 95%
Size 1
10 µg
Size 2
50 µg
Size 3
100 µg
Size 4
200 µg
Size 5
500 µg
Form
Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.
Tested Applications
WB, SDS-PAGE
Buffer
Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300.
Availability
Shipped within 5-7 working days.
Storage
Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.
Dry Ice
No
UniProt ID
E9Q0N2
Alias
SAP1,R-PTP-H,Stomach cancer-associated protein tyrosine phosphatase 1,Transmembrane-type protein-tyrosine phosphatase type H,Receptor-type tyrosine-protein phosphatase H
Background
Protein PTPRH
Status
RUO
Note
This product is for research use only.   Not for human consumption, cosmetic, therapeutic or diagnostic use.

Descripción

PTPRH, also known as stomach cancer-associated protein tyrosine phosphatase-1 (SAP-1), is a receptor-like protein tyrosine phosphatase predominantly expressed in epithelial cells of the gastrointestinal tract. Structurally, PTPRH comprises an extracellular domain with multiple fibronectin type III repeats, a transmembrane region, and two intracellular phosphatase domains. PTPRH plays a role in epithelial cell signaling by regulating the activity of receptor tyrosine kinases, including EGFR (epidermal growth factor receptor). This regulation influences processes such as cell growth, differentiation, and migration. PTPRH is implicated in maintaining epithelial homeostasis and is overexpressed in gastrointestinal cancers, particularly gastric and colorectal cancers. Its dysregulation contributes to abnormal epithelial proliferation and cancer progression, making it a potential therapeutic target in oncology.

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