Mouse Proteinase-Activated Receptor 2 / PAR2 (F2RL1) Protein
Pida mas información
935106861
info@markelab.com
Precio
208€ (10 µg)
Protein F2RL1
proveedor
Abbexareference
abx654827Tested Applications
WB, SDS-PAGEreactivity
status
RUOclonality
Descripción
Mouse Proteinase-Activated Receptor 2 / PAR2 (F2RL1) Protein is a Recombinant Mouse protein expressed in E. coli.
Background
Proteinase-Activated Receptor 2 (F2RL1), also known as PAR2, is a G protein-coupled receptor (GPCR) activated by the cleavage of its N-terminal domain by serine proteases, such as trypsin and mast cell tryptase. PAR2 is widely expressed in various tissues, including endothelial cells, platelets, smooth muscle, and immune cells, where it regulates inflammatory responses, cell migration, and pain perception. Upon activation, F2RL1 couples to Gq, Gi, and G12/13 proteins, stimulating phospholipase C (PLC), MAPK, and Rho signaling pathways. These pathways lead to increased intracellular calcium, cell contraction, and gene expression associated with inflammation. F2RL1 plays a role in immune cell recruitment during allergic reactions, wound healing, and tissue remodeling. Dysregulation of F2RL1 has been implicated in inflammatory diseases, cancer metastasis, and pain disorders. PAR2 antagonists are being developed for therapeutic applications in conditions like asthma, chronic pain, and cancer, by modulating its pro-inflammatory effects and enhancing tissue repair.
Características del producto
category
Proteins and Peptides
origin
Mouse
host
E. coli
immunogen target
Proteinase-Activated Receptor 2 / PAR2 (F2RL1)
host
E. coli
conjugation
Unconjugated
form
Lyophilized Reconstitute in ddH2O to a concentration of 0.1-1.0 mg/ml. Do not vortex.
tested applications
WB, SDS-PAGE
size 1
10 µg
size 2
50 µg
size 3
100 µg
size 4
200 µg
size 5
500 µg
observerd MW
Molecular Weight: Calculated MW: 40.0 kDa Observed MW (SDS-PAGE): 42 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Val311-Tyr399 Tag: N-terminal His tag and GST tag
expression
Recombinant
purity
> 90%
buffer
Prior to lyophilization: 20 mM Tris, 150 mM NaCl, pH 8.0, containing 0.01% Sarcosyl, 5% Trehalose.
storage
Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.
or code
F2RL1
dry ice
No
availability
Shipped within 5-7 working days.
alias
F2RL1,GPR11,coagulation factor II receptor-like 1,Protease-activated receptor-2 ,thrombin receptor-like 1,PAR2
uniprot id
NCBI accession
NP_032000.3
note
This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use.
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