Mouse Prokineticin receptor 2 (PROKR2) ELISA Kit
715€ (96 tests)
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935106861
info@markelab.com
name
Mouse Prokineticin receptor 2 (PROKR2) ELISA Kit
category
ELISA Kits
provider
Abbexa
reference
abx539129
tested applications
ELISA
Description
Mouse Prokineticin receptor 2 (PROKR2) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Mouse Prokineticin receptor 2 concentrations in tissue homogenates, cell lysates and other biological fluids.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | ELISA Kits |
| Immunogen Target | Prokineticin receptor 2 (PROKR2) |
| Reactivity | Mouse |
| Detection Method | Colorimetric |
| Assay Data | Quantitative |
| Test Range | 0.156 ng/ml - 10 ng/ml |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 96 tests |
| Form | Lyophilized |
| Tested Applications | ELISA |
| Sample Type | Tissue homogenates, cell lysates and other biological fluids. |
| Availability | Shipped within 5-15 working days. The validity for this kit is 6 months. |
| Storage | Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| UniProt ID | Q8K458 |
| Gene ID | 246313 |
| Alias | PROKR2,GPR73b,VEGFR-2,GPR73a,GPRg2,I5E |
| Background | Elisa kits for PROKR2 |
| Status | RUO |
| Note | Validity: The validity for this kit is 6 months. This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. |
Descripción
PROKR2, another G protein-coupled receptor for prokineticins, shares functional overlap with PROKR1 but has distinct tissue distribution and physiological roles. It is highly expressed in the central nervous system, particularly in the hypothalamus and olfactory bulb, where it regulates circadian rhythms, neurogenesis, and reproductive function. PROKR2 couples to Gq and Gi/o proteins, stimulating phospholipase C (PLC) and MAPK pathways to regulate neuronal signaling, calcium homeostasis, and cellular responses. PROKR2 is crucial for hypothalamic-pituitary-gonadal axis function, influencing puberty onset and fertility. Mutations in PROKR2 are associated with Kallmann syndrome, characterized by delayed puberty and anosmia (loss of smell). PROKR2 also plays a role in thermoregulation, stress responses, and inflammation. Dysregulation of PROKR2 signaling contributes to reproductive disorders, sleep disturbances, and neuroinflammatory diseases. Targeting PROKR2 holds therapeutic promise for conditions such as infertility, sleep regulation disorders, and neurodevelopmental syndromes.
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