Mouse Pigment Epithelium-Derived Factor / PEDF (SERPINF1) Protein (Active)
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Description
Mouse PEDF Protein is a recombinant protein from Mouse produced in HEK293 Cells. A DNA sequence encoding the extracellular domain (Met 1-Thr 417) of mouse Pigment Epithelium-Derived Factor / PEDF (SERPINF1) (NP_035470.3) precursor was expressed with a C-terminal polyhistidine tag.
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Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | Pigment Epithelium-Derived Factor / PEDF (SERPINF1) |
| Host | HEK293 cells |
| Origin | Mouse |
| Observed MW | Molecular Weight: 45.8 kDa Sequence Fragment: Met1-Thr417 Tag: C-terminal His tag Validity: The validity for this protein is 12 months. |
| Expression | Recombinant |
| Purity | > 95% (SDS-PAGE) |
| Size 1 | 50 µg |
| Form | |
| Tested Applications | SDS-PAGE |
| Buffer | Lyophilized from sterile PBS, pH 7.4. |
| Availability | Shipped within 5-15 working days. |
| Storage | Aliquot and store at -20°C or -80°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P97298 |
| Gene ID | 20317 |
| NCBI Accession | NP_035470.3 |
| Alias | OI6,OI12,PEDF,EPC-1,PIG35,Pigment epithelium-derived factor,Cell proliferation-inducing gene 35 protein,Serpin F1 |
| Background | Protein SERPINF1 |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
SERPINF1, also known as pigment epithelium-derived factor (PEDF), is a member of the serpin (serine protease inhibitor) family, though it has unique properties distinct from classical serpins. Unlike most serpins, SERPINF1 does not function as a typical protease inhibitor but is instead a multifunctional protein with potent anti-angiogenic, neuroprotective, and anti-inflammatory effects. First identified in the pigment epithelium of the eye, it has since been found in a variety of tissues and is now recognized as a crucial player in many biological processes, including the inhibition of abnormal blood vessel growth and tissue protection. SERPINF1 is highly expressed in the eye, particularly in the retinal pigment epithelium (RPE) and other neural tissues. It is most famous for its role in ocular health, but its functions extend to other organs, such as the liver, heart, skin, and brain.
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Pigment Epithelium-Derived Factor / PEDF (SERPINF1) Antibody is a Rabbit Polyclonal antibody against SERPINF1. Pigment epithelium-derived growth factor (PEDF), also known as EPC-1 (early population doubling level cDNA-1), is a glycoprotein found naturally in the normal eye. PEDF has reported neuroprotective and differentiation properties and is secreted in abundance by retinal pigment epithelium cells. It belongs to the serine protease inhibitor (Serpin) superfamily and has been reported to inhibit angiogenesis and proliferation of several cell types. The pooling of PEDF within the interphotoreceptor matrix places this molecule in a prime physical location to affect the underlying neural retina. Additionally, PEDF induces neuronal differentiation and promotes survival of neurons of the central nervous system from degeneration caused by serum withdrawal or glutamate cytotoxicity.
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