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Pigment Epithelium-Derived Factor / PEDF (SERPINF1) Antibody
proveedor
Abbexareference
abx033320Tested Applications
ELISA, WB, IHC, FCMreactivity
Humanstatus
RUOclonality
PolyclonalDescripción
Pigment Epithelium-Derived Factor / PEDF (SERPINF1) is a member of the serpin family. Serpins are a group of serine protease inhibitors, some of which have also been reported to exhibit neurotrophic activity.
Background
Inhibitory serpins have been shown to function in processes as diverse as DNA binding, chromatin condensation, immunoregulation ,apoptosis and haemostasis. Serpins are a broadly distributed protease inhibitors that use the conformational change as a mechanism of action. They are central in controlling many important proteolytic cascades. Phylogenetically Serpins superfamily organized in "Clades", named by letters. The following numbers shows the position in the glade. Serpin named as a SERPINXy, (where X is the clade and y is the number within that clade) many serpins also have alternative names from before this classification was proposed. Structuraly Serpinsare three β-sheets (A, B and C), 8-9 α-helices (termed hA-hI) and the reactive center known as reactive center loop (RCL). Pigment epithelium-derived factor (PEDF) also known as serpin F1 (SERPINF1), is a multifunctional secreted protein that has anti-angiogenic, anti-tumorigenic, and neurotrophic functions
Background
Se ha demostrado que las serpinas inhibidoras funcionan en procesos tan diversos como la unión al ADN, la condensación de cromatina, la inmunorregulación, la apoptosis y la hemostasia. Las serpinas son inhibidores de proteasas ampliamente distribuidos que utilizan el cambio conformacional como mecanismo de acción. Son fundamentales para controlar muchas cascadas proteolíticas importantes. Filogenéticamente superfamilia de Serpinas organizada en "Clados", nombradas por letras. Los siguientes números muestran la posición en el claro. Serpin nombrada como SERPINXy (donde X es el clado e y es el número dentro de ese clado). Muchas serpinas también tienen nombres alternativos antes de que se propusiera esta clasificación. Estructuralmente, las Serpins son tres láminas β (A, B y C), 8-9 hélices α (denominadas hA-hI) y el centro reactivo conocido como bucle del centro reactivo (RCL). El factor derivado del epitelio pigmentario (PEDF), también conocido como serpina F1 (SERPINF1), es una proteína secretada multifuncional que tiene funciones antiangiogénicas, antitumorales y neurotróficas.
Características del producto
category
Primary Antibodies
clonality
Polyclonal
reactivity
Human
immunogen target
Pigment Epithelium-Derived Factor / PEDF (SERPINF1)
host
Rabbit
conjugation
Unconjugated
form
Liquid
tested applications
ELISA, WB, IHC, FCM
purification
Purified Rabbit Polyclonal Antibody.
buffer
PBS containing 0.09% sodium azide.
size 1
80 µl
size 2
400 µl
storage
Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
or code
SERPINF1
dry ice
No
availability
Shipped within 5-10 working days.
alias
OI6,OI12,PEDF,EPC-1,PIG35,Pigment epithelium-derived factor,Cell proliferation-inducing gene 35 protein,Serpin F1
uniprot id
note
This product is for research use only.
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