Mouse PHD Finger Protein 8 (PHF8) Protein

Este producto es parte de PHF - PHD finger protein
Mouse PHD Finger Protein 8 (PHF8) Protein

Pida mas información

935106861

info@markelab.com

Precio

221€ (10 µg)

Protein PHF8

proveedor

Abbexa

reference

abx650728

Tested Applications

WB, SDS-PAGE

reactivity

status

RUO

clonality

Descripción

Mouse PHF8 Protein is a recombinant Mouse protein produced in a Prokaryotic expression system (E. coli).


Background

PHF8 is a histone demethylase containing a PHD finger domain that recognizes H3K4me3 and demethylates repressive marks such as H3K9me2/1 to activate transcription. It plays a role in gene regulation during cell cycle progression, neuronal development, and DNA damage repair by promoting chromatin accessibility. PHF8 is expressed in neural tissues and contributes to neurogenesis, synaptic plasticity, and cognitive function. Mutations in PHF8 are associated with X-linked intellectual disability and cleft lip/palate syndromes, where impaired histone demethylation leads to defective gene expression during development. Dysregulation of PHF8 is also implicated in cancer, where it promotes tumor growth and proliferation through transcriptional activation of oncogenes. Knockdown studies demonstrate impaired DNA repair, cell cycle arrest, and defects in neuronal differentiation, highlighting its critical role in histone demethylation, chromatin regulation, and developmental processes.

Características del producto

category

Proteins and Peptides


origin

Mouse


host

E. coli


immunogen target

PHD Finger Protein 8 (PHF8)


host

E. coli


conjugation

Unconjugated


form

Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.


tested applications

WB, SDS-PAGE


size 1

10 µg


size 2

50 µg


size 3

100 µg


size 4

200 µg


size 5

500 µg


observerd MW

Molecular Weight: Calculated MW: 22.0 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Phe195-Lys351 Tag: N-terminal His tag


expression

Recombinant


purity

> 95%


buffer

Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300.


storage

Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.


or code

PHF8


dry ice

No


availability

Shipped within 5-7 working days.


alias

JHDM1F,KDM7B MRXSSD,ZNF422,Histone lysine demethylase PHF8


note

This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use.


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