Mouse PHD Finger Protein 8 (PHF8) Protein
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935106861
info@markelab.com
Precio
221€ (10 µg)
Protein PHF8
proveedor
Abbexareference
abx650728Tested Applications
WB, SDS-PAGEreactivity
status
RUOclonality
Descripción
Mouse PHF8 Protein is a recombinant Mouse protein produced in a Prokaryotic expression system (E. coli).
Background
PHF8 is a histone demethylase containing a PHD finger domain that recognizes H3K4me3 and demethylates repressive marks such as H3K9me2/1 to activate transcription. It plays a role in gene regulation during cell cycle progression, neuronal development, and DNA damage repair by promoting chromatin accessibility. PHF8 is expressed in neural tissues and contributes to neurogenesis, synaptic plasticity, and cognitive function. Mutations in PHF8 are associated with X-linked intellectual disability and cleft lip/palate syndromes, where impaired histone demethylation leads to defective gene expression during development. Dysregulation of PHF8 is also implicated in cancer, where it promotes tumor growth and proliferation through transcriptional activation of oncogenes. Knockdown studies demonstrate impaired DNA repair, cell cycle arrest, and defects in neuronal differentiation, highlighting its critical role in histone demethylation, chromatin regulation, and developmental processes.
Características del producto
category
Proteins and Peptides
origin
Mouse
host
E. coli
immunogen target
PHD Finger Protein 8 (PHF8)
host
E. coli
conjugation
Unconjugated
form
Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.
tested applications
WB, SDS-PAGE
size 1
10 µg
size 2
50 µg
size 3
100 µg
size 4
200 µg
size 5
500 µg
observerd MW
Molecular Weight: Calculated MW: 22.0 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Phe195-Lys351 Tag: N-terminal His tag
expression
Recombinant
purity
> 95%
buffer
Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300.
storage
Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.
or code
PHF8
dry ice
No
availability
Shipped within 5-7 working days.
alias
JHDM1F,KDM7B MRXSSD,ZNF422,Histone lysine demethylase PHF8
uniprot id
note
This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use.
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