Mouse PHD Finger Protein 8 (PHF8) Protein
221€ (10 µg)
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935106861
info@markelab.com
name
Mouse PHD Finger Protein 8 (PHF8) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx650728
tested applications
WB, SDS-PAGE
Description
Mouse PHF8 Protein is a recombinant Mouse protein produced in a Prokaryotic expression system (E. coli).
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | PHD Finger Protein 8 (PHF8) |
| Host | E. coli |
| Origin | Mouse |
| Conjugation | Unconjugated |
| Observed MW | Molecular Weight: Calculated MW: 22.0 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Phe195-Lys351 Tag: N-terminal His tag |
| Expression | Recombinant |
| Purity | > 95% |
| Size 1 | 10 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 500 µg |
| Form | Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex. |
| Tested Applications | WB, SDS-PAGE |
| Buffer | Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300. |
| Availability | Shipped within 5-7 working days. |
| Storage | Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q80TJ7 |
| Alias | JHDM1F,KDM7B MRXSSD,ZNF422,Histone lysine demethylase PHF8 |
| Background | Protein PHF8 |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
PHF8 is a histone demethylase containing a PHD finger domain that recognizes H3K4me3 and demethylates repressive marks such as H3K9me2/1 to activate transcription. It plays a role in gene regulation during cell cycle progression, neuronal development, and DNA damage repair by promoting chromatin accessibility. PHF8 is expressed in neural tissues and contributes to neurogenesis, synaptic plasticity, and cognitive function. Mutations in PHF8 are associated with X-linked intellectual disability and cleft lip/palate syndromes, where impaired histone demethylation leads to defective gene expression during development. Dysregulation of PHF8 is also implicated in cancer, where it promotes tumor growth and proliferation through transcriptional activation of oncogenes. Knockdown studies demonstrate impaired DNA repair, cell cycle arrest, and defects in neuronal differentiation, highlighting its critical role in histone demethylation, chromatin regulation, and developmental processes.
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