Mouse PHD finger protein 1 (PHF1) ELISA Kit

Este producto es parte de PHF - PHD finger protein
Mouse PHD finger protein 1 (PHF1) ELISA Kit

Pida mas información

935106861

info@markelab.com

Precio

715€ (96 tests)

Elisa kits for PHF1

proveedor

Abbexa

reference

abx516405

Tested Applications

ELISA

reactivity

Mouse

status

RUO

clonality

Descripción

Mouse PHD finger protein 1 (PHF1) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Mouse PHD finger protein 1 concentrations in tissue homogenates, cell lysates and other biological fluids.


Background

PHF1 is a chromatin-binding protein that contains a plant homeodomain (PHD) finger, allowing it to recognize methylated histone residues, particularly H3K36me3. PHF1 is part of the Polycomb repressive complex 2 (PRC2), which regulates gene expression through chromatin modification and silencing. It facilitates PRC2 recruitment to specific genomic loci, contributing to epigenetic regulation of development, differentiation, and proliferation. PHF1 is highly expressed in tissues with active epigenetic remodeling, such as embryonic stem cells and immune cells. Dysregulation of PHF1 has been associated with sarcomas and other cancers, where its aberrant activity affects transcriptional repression and genome stability. Knockdown studies reveal defects in PRC2-mediated H3K27 methylation, leading to disrupted chromatin states and altered gene expression profiles, highlighting its essential role in epigenetic regulation, cellular identity, and cancer development.

Características del producto

category

ELISA Kits


immunogen target

PHD finger protein 1 (PHF1)


reactivity

Mouse


test range

0.312 ng/ml - 20 ng/ml


assay type

Sandwich


assay data

Quantitative


form

Lyophilized


detection method

Colorimetric


sample type

Tissue homogenates, cell lysates and other biological fluids.


size 1

96 tests


alias

PCL1,PHF1,hPHF1,PCL1; PHF2,MTF2L2; TDRD19C


storage

Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual.


or code

PHF1


dry ice

No


note

This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.


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