Human PHD finger protein 1 (PHF1) ELISA Kit

Este producto es parte de PHF - PHD finger protein
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715€ (96 tests)

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935106861
info@markelab.com
name
Human PHD finger protein 1 (PHF1) ELISA Kit
category
ELISA Kits
provider
Abbexa
reference
abx250780
tested applications
ELISA

Description

Human PHD finger protein 1 (PHF1) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human PHD finger protein 1 concentrations in tissue homogenates, cell lysates and other biological fluids.

Documents del producto

Instrucciones
Data sheet
Descargar

Product specifications

Category
ELISA Kits
Immunogen Target
PHD finger protein 1 (PHF1)
Reactivity
Human
Detection Method
Colorimetric
Assay Data
Quantitative
Assay Type
Sandwich
Test Range
0.312 ng/ml - 20 ng/ml
Recommended Dilution
Optimal dilutions/concentrations should be determined by the end user.
Size 1
96 tests
Form
Lyophilized
Tested Applications
ELISA
Sample Type
Tissue homogenates, cell lysates and other biological fluids.
Availability
Shipped within 5-12 working days. The validity for this kit is 6 months.
Storage
Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual.
Dry Ice
No
UniProt ID
O43189
Alias
PCL1,PHF1,hPHF1,PCL1; PHF2,MTF2L2; TDRD19C
Background
Elisa kits for PHF1
Status
RUO
Note
Validity: The validity for this kit is 6 months.
This product is for research use only.   The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments.   Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.

Descripción

PHF1 is a chromatin-binding protein that contains a plant homeodomain (PHD) finger, allowing it to recognize methylated histone residues, particularly H3K36me3. PHF1 is part of the Polycomb repressive complex 2 (PRC2), which regulates gene expression through chromatin modification and silencing. It facilitates PRC2 recruitment to specific genomic loci, contributing to epigenetic regulation of development, differentiation, and proliferation. PHF1 is highly expressed in tissues with active epigenetic remodeling, such as embryonic stem cells and immune cells. Dysregulation of PHF1 has been associated with sarcomas and other cancers, where its aberrant activity affects transcriptional repression and genome stability. Knockdown studies reveal defects in PRC2-mediated H3K27 methylation, leading to disrupted chromatin states and altered gene expression profiles, highlighting its essential role in epigenetic regulation, cellular identity, and cancer development.

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