PHD Finger Protein 1 (PHF1) Antibody
52€ (10 µg)
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935106861
info@markelab.com
name
PHD Finger Protein 1 (PHF1) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx013289
tested applications
ELISA, WB
Description
Rabbit polyclonal antibody against PHF1 protein. Immunogen region is Internal.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | PHD Finger Protein 1 (PHF1) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | WB: 1/500 - 1/3000, ELISA: 1/10000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified from rabbit antiserum by affinity chromatography using epitope-specific immunogen. |
| Size 1 | 10 µg |
| Size 2 | 100 µg |
| Size 3 | 200 µg |
| Size 4 | 300 µg |
| Size 5 | 1 mg |
| Form | Liquid |
| Tested Applications | ELISA, WB |
| Buffer | PBS (without Mg<sup>2+</sup> and Ca<sup>2+</sup>), pH 7.4, 150 mM NaCl, 0.02% sodium azide, 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | O43189 |
| Alias | PCL1,PHF1,hPHF1,PCL1; PHF2,MTF2L2; TDRD19C |
| Background | Antibody anti-PHF1 |
| Status | RUO |
| Note | Concentration: 1 mg/ml - |
Descripción
PHF1 is a chromatin-binding protein that contains a plant homeodomain (PHD) finger, allowing it to recognize methylated histone residues, particularly H3K36me3. PHF1 is part of the Polycomb repressive complex 2 (PRC2), which regulates gene expression through chromatin modification and silencing. It facilitates PRC2 recruitment to specific genomic loci, contributing to epigenetic regulation of development, differentiation, and proliferation. PHF1 is highly expressed in tissues with active epigenetic remodeling, such as embryonic stem cells and immune cells. Dysregulation of PHF1 has been associated with sarcomas and other cancers, where its aberrant activity affects transcriptional repression and genome stability. Knockdown studies reveal defects in PRC2-mediated H3K27 methylation, leading to disrupted chromatin states and altered gene expression profiles, highlighting its essential role in epigenetic regulation, cellular identity, and cancer development.
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