Mouse Metabotropic glutamate receptor 5 (GRM5) ELISA Kit

Este producto es parte de GRM - Glutamate Receptor Metabotropic
Mouse Metabotropic glutamate receptor 5 (GRM5) ELISA Kit
715€ (96 tests)

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Name
Mouse Metabotropic glutamate receptor 5 (GRM5) ELISA Kit
Category
ELISA Kits
Provider
Abbexa
Reference
abx254982
Tested Applications
ELISA

Description

Mouse Metabotropic glutamate receptor 5 (GRM5) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Mouse Metabotropic glutamate receptor 5 concentrations in tissue homogenates, cell lysates and other biological fluids.

Documentos del producto

Instrucciones
Data sheet
Descargar

Especificaciones del producto

Category
ELISA Kits
Immunogen Target
Metabotropic glutamate receptor 5 (GRM5)
Reactivity
Mouse
Detection Method
Colorimetric
Assay Data
Quantitative
Assay Type
Sandwich
Test Range
0.156 ng/ml - 10 ng/ml
Recommended Dilution
Optimal dilutions/concentrations should be determined by the end user.
Size 1
96 tests
Form
Standard Form: Lyophilized
Tested Applications
ELISA
Sample Type
Tissue homogenates, cell lysates and other biological fluids.
Availability
Shipped within 5-12 working days.
Storage
Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual.
Dry Ice
No
UniProt ID
Q3UVX5
Alias
GRM5,GPRC1E,MGLUR5,PPP1R86,mGlu5
Background
Elisa Kits for: GRM5
Status
RUO
Note
THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.
The stability of the kit is determined by the rate of activity loss. The loss rate is less than 5% within the expiration date under appropriate storage conditions. To minimize performance fluctuations, operation procedures and lab conditions should be strictly controlled. It is also strongly suggested that the whole assay is performed by the same user throughout.

Background

GRM5, or mGluR5, is a Group I metabotropic glutamate receptor that couples to Gq proteins, activating phospholipase C (PLC), increasing intracellular calcium levels, and triggering downstream signaling pathways such as MAPK and PI3K/Akt. GRM5 is primarily expressed in the hippocampus, cortex, and basal ganglia, where it regulates synaptic plasticity, learning, and memory formation. It also modulates long-term potentiation (LTP) and excitotoxic responses. Dysregulation of GRM5 is implicated in neurological and psychiatric disorders, including fragile X syndrome, autism spectrum disorders (ASD), schizophrenia, and addiction. GRM5 overactivation can exacerbate excitotoxicity, leading to neurodegeneration in diseases like Alzheimer’s and Parkinson’s. Antagonists of GRM5, such as selective negative allosteric modulators (NAMs), are being explored for treating neurodevelopmental disorders, anxiety, and addiction. Targeting GRM5 holds significant promise for improving synaptic function and reducing excitotoxic damage in CNS-related diseases.

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