Mouse Melatonin Receptor 1A (MTNR1A) Protein

Este producto es parte de MTNR - Melatonin Receptor
Product Graph
247€ (10 µg)

Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.

935106861
info@markelab.com
name
Mouse Melatonin Receptor 1A (MTNR1A) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx067987
tested applications
WB, SDS-PAGE

Description

Mouse Melatonin Receptor 1A (MTNR1A) is a recombinant Mouse protein expressed in E. coli.

Documents del producto

Instrucciones
Data sheet
Descargar

Product specifications

Category
Proteins and Peptides
Immunogen Target
Melatonin Receptor 1A (MTNR1A)
Host
E. coli
Assay Type
Activity: Not tested
Sequence Fragment: Leu300-Val353
Tag: N-terminal His tag
Origin
Mouse
Conjugation
Unconjugated
Observed MW
Calculated MW: 13.0 kDa  Observed MW (SDS-PAGE): 13 kDa
Expression
Recombinant
Purity
> 90%
Size 1
10 µg
Size 2
50 µg
Size 3
100 µg
Size 4
200 µg
Size 5
500 µg
Form
Lyophilized
Tested Applications
WB, SDS-PAGE
Buffer
Prior to lyophilization: 20 mM Tris, 150 mM NaCl, pH 8.0, containing 1 mM EDTA, 1 mM DTT, 0.01% Sarcosyl, 5% Trehalose and Proclin-300.
Availability
Shipped within 5-7 working days.
Storage
Store lyophilized form at 2-8°C for up to 1 month. For longer periods, store lyophilized or liquid at -80°C. Avoid repeated freeze–thaw cycles.
Dry Ice
No
UniProt ID
Q61184
Alias
MTNR1A,mel1a receptor,MelR,MEL-1A-R, MT1
Background
Protein MTNR1A
Status
RUO
Note
THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION.
To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in 20 mM Tris, 150 mM NaCl, pH 8.0. If a higher concentration is required, the product can be reconstituted directly in 20 mM Tris, 150 mM NaCl, pH 8.0, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.
Concentration: Prior to lyophilization: 200 µg/ml

Descripción

MTNR1A, also known as MT1, is a G protein-coupled receptor for melatonin, a hormone secreted by the pineal gland that regulates circadian rhythms and sleep-wake cycles. MTNR1A is primarily expressed in the suprachiasmatic nucleus (SCN) of the hypothalamus, where it mediates melatonin’s effects on synchronizing circadian rhythms with environmental light-dark cycles. Activation of MTNR1A inhibits adenylate cyclase via Gi proteins, reducing cAMP levels and modulating downstream signaling pathways that regulate neuronal excitability and gene expression. MTNR1A is critical for sleep initiation, thermoregulation, and seasonal reproduction in some species. Dysregulation of MTNR1A has been associated with sleep disorders, circadian rhythm disturbances, and mood disorders such as depression. MTNR1A agonists like ramelteon are used clinically to treat insomnia and jet lag by promoting sleep onset. Its role in circadian and endocrine regulation highlights MTNR1A as a key target for managing sleep disorders, metabolic health, and mood-related conditions.

Related Products

EH4548

Human MTNR1A (Melatonin receptor type 1A) ELISA Kit

Ver Producto
FNab10523

MTNR1A antibody

Ver Producto
abx015347

Melatonin Receptor 1A (MTNR1A) Antibody

Rabbit polyclonal antibody against MTNR1A protein. Immunogen region is Internal.

Ver Producto