Mouse LIM and senescent cell antigen-like-containing domain protein 1 (LIMS1) ELISA Kit
Pida mas información
935106861
info@markelab.com
Precio
715€ (96 tests)
Elisa kits for LIMS1
proveedor
Abbexareference
abx531032Tested Applications
ELISAreactivity
Mousestatus
RUOclonality
Descripción
Mouse LIM and senescent cell antigen-like-containing domain protein 1 (LIMS1) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Mouse LIM and senescent cell antigen-like-containing domain protein 1 concentrations in tissue homogenates, cell lysates and other biological fluids.
Background
LIMS1, also known as PINCH1 (Particularly Interesting New Cysteine-Histidine rich protein), is a LIM domain-containing adaptor protein involved in integrin-mediated cell adhesion and signaling. LIMS1 interacts with focal adhesion proteins such as ILK (integrin-linked kinase) and acts as a scaffold to regulate cell-ECM adhesion, cytoskeletal organization, and signaling pathways like PI3K/Akt, MAPK/ERK, and TGF-β. It is broadly expressed in tissues and plays critical roles in cell survival, migration, differentiation, and embryonic development. LIMS1 is essential for cardiac and skeletal muscle development, where it stabilizes focal adhesions and modulates mechanical signaling. Dysregulation of LIMS1 is associated with cancer progression, metastasis, and fibrosis due to its role in integrin signaling and actin cytoskeleton remodeling. Knockout models show embryonic lethality, severe developmental defects, and impaired adhesion, highlighting its importance in tissue homeostasis.
Características del producto
category
ELISA Kits
immunogen target
LIM and senescent cell antigen-like-containing domain protein 1 (LIMS1)
reactivity
Mouse
test range
0.156 ng/ml - 10 ng/ml
assay data
Quantitative
form
Lyophilized
detection method
Colorimetric
sample type
Tissue homogenates, cell lysates and other biological fluids.
size 1
96 tests
alias
LIMS1,PINCH,INCH1,PINCH-1,LIM and senescent cell antigen-like-containing domain protein 1
storage
Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual.
or code
LIMS1
dry ice
No
uniprot id
note
This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.
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