Human LIM And Senescent Cell Antigen Like Domains Protein 1 (LIMS1) Protein

Pida mas información
935106861
info@markelab.com
Precio
234€ (10 µg)
Protein LIMS1
proveedor
Abbexareference
abx067782Tested Applications
WB, SDS-PAGEreactivity
status
RUOclonality
Descripción
Recombinant LIM And Senescent Cell Antigen Like Domains Protein 1 (LIMS1) is a recombinant Human protein produced in a Prokaryotic expression system (E. coli).
Background
LIMS1, also known as PINCH1 (Particularly Interesting New Cysteine-Histidine rich protein), is a LIM domain-containing adaptor protein involved in integrin-mediated cell adhesion and signaling. LIMS1 interacts with focal adhesion proteins such as ILK (integrin-linked kinase) and acts as a scaffold to regulate cell-ECM adhesion, cytoskeletal organization, and signaling pathways like PI3K/Akt, MAPK/ERK, and TGF-β. It is broadly expressed in tissues and plays critical roles in cell survival, migration, differentiation, and embryonic development. LIMS1 is essential for cardiac and skeletal muscle development, where it stabilizes focal adhesions and modulates mechanical signaling. Dysregulation of LIMS1 is associated with cancer progression, metastasis, and fibrosis due to its role in integrin signaling and actin cytoskeleton remodeling. Knockout models show embryonic lethality, severe developmental defects, and impaired adhesion, highlighting its importance in tissue homeostasis.
Características del producto
category
Proteins and Peptides
origin
Human
host
E. coli
immunogen target
LIM And Senescent Cell Antigen Like Domains Protein 1 (LIMS1)
host
E. coli
conjugation
Unconjugated
form
Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in 20 mM Tris, 150 mM NaCl, pH 8.0. If a higher concentration is required, the product can be reconstituted directly in 20 mM Tris, 150 mM NaCl, pH 8.0, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.
tested applications
WB, SDS-PAGE
size 1
10 µg
size 2
50 µg
size 3
100 µg
size 4
200 µg
size 5
500 µg
observerd MW
Molecular Weight: Calculated MW: 30.5 kDa Observed MW (SDS-PAGE): 28 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Ala68-Cys303 Tag: N-terminal His tag
expression
Recombinant
purity
> 90%
buffer
Prior to lyophilization: 20 mM Tris, 150 mM NaCl, pH 8.0, containing 1 mM EDTA, 1 mM DTT, 0.01% Sarcosyl, 5% Trehalose and Proclin-300.
storage
Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.
or code
LIMS1
dry ice
No
availability
Shipped within 5-7 working days.
alias
LIMS1,PINCH,INCH1,PINCH-1,LIM and senescent cell antigen-like-containing domain protein 1
uniprot id
note
This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use.
Quizá le pueda interesar
anti- LIMS1 antibody

proveedor
FineTestreference
FNab04782Tested Applications
ELISA, WB, IF, IHCreactivity
human,mouse,ratstatus
RUOclonality
polyclonalThe protein encoded by this gene is an adaptor protein which contains five LIM domains, or double zinc fingers. The prot...
Precio a consultar
Ver másLIM Zinc Finger Domain Containing 1 (LIMS1) Antibody

proveedor
Abbexareference
abx004882Tested Applications
ELISA, WB, IF/ICCreactivity
Human, Mouse, Ratstatus
RUOclonality
PolyclonalLIMS1 Antibody is a Rabbit Polyclonal antibody against LIMS1. The protein encoded by this gene is an adaptor protein whi...
195€ (20 µl)
Ver másHuman LIM And Senescent Cell Antigen Like Domains Protein 1 (LIMS1) Protein

proveedor
Abbexareference
abx067782Tested Applications
WB, SDS-PAGEstatus
RUORecombinant LIM And Senescent Cell Antigen Like Domains Protein 1 (LIMS1) is a recombinant Human protein produced in a P...
234€ (10 µg)
Ver más