Mouse Interleukin 1 Receptor Accessory Protein (IL1RAP) CLIA Kit
845€ (96 tests)
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935106861
info@markelab.com
name
Mouse Interleukin 1 Receptor Accessory Protein (IL1RAP) CLIA Kit
category
CLIA Kits
provider
Abbexa
reference
abx190513
tested applications
CLIA
Description
Mouse Interleukin 1 Receptor Accessory Protein (IL1RAP) Chemiluminescent Immunoassay (CLIA) Kit is a Sandwich Chemiluminescent Immunoassay (CLIA) Kit for use with Serum, plasma, tissue homogenates and other biological fluids.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | CLIA Kits |
| Immunogen Target | Interleukin 1 Receptor Accessory Protein (IL1RAP) |
| Reactivity | Mouse |
| Detection Method | Chemiluminescent |
| Assay Data | Quantitative |
| Assay Type | Sandwich |
| Test Range | 2.74 pg/ml - 2000 pg/ml |
| Sensitivity | < 1.23 pg/ml |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 96 tests |
| Size 2 | 5 × 96 tests |
| Size 3 | 10 × 96 tests |
| Form | Lyophilized |
| Tested Applications | CLIA |
| Sample Type | Serum, plasma, tissue homogenates and other biological fluids. |
| Availability | Shipped within 5-7 working days. |
| Storage | Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| Alias | C3orf13, IL-1R-3, IL-1R3, IL-1RAcP,IL1RAP,Interleukin-1 receptor 3,IL-1 receptor accessory protein,IL-1RAcP |
| Background | CLIA Kits IL1RAP |
| Status | RUO |
| Note | The validity for this kit is at least 6 months. Up to 12 months validity can be provided on request. This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. |
Descripción
IL1RAP is a coreceptor that amplifies the interleukin-1 (IL-1) signaling cascade, which mediates inflammatory, immune, and stress responses. It forms a complex with the interleukin-1 receptor (IL-1R) and IL-1 ligand, facilitating the recruitment of the adaptor protein MyD88 and downstream activation of NF-κB, MAPK, and JNK pathways. These pathways lead to the transcription of pro-inflammatory cytokines, chemokines, and immune mediators critical for host defense. IL1RAP is widely expressed in immune cells such as monocytes, macrophages, dendritic cells, and T cells, playing pivotal roles in acute and chronic inflammatory responses, immune surveillance, and tissue repair. Beyond immunity, IL1RAP is overexpressed in cancers such as acute myeloid leukemia (AML) and solid tumors, where it enhances tumor proliferation and survival by supporting inflammatory microenvironments. Its role as a therapeutic target in inflammation and oncology is under investigation. Knockdown studies demonstrate impaired IL-1 signaling, reduced cytokine production, and weakened immune activation, underscoring its role as a crucial signaling scaffold in inflammation, immunity, and disease pathology.
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