Human Interleukin 1 Receptor Accessory Protein (IL1RAP) Protein
234€ (10 µg)
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name
Human Interleukin 1 Receptor Accessory Protein (IL1RAP) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx067399
tested applications
WB, SDS-PAGE
Description
Recombinant Interleukin 1 Receptor Accessory Protein (IL1RAP) is a recombinant Human protein produced in a Prokaryotic expression system (E. coli).
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | Interleukin 1 Receptor Accessory Protein (IL1RAP) |
| Host | E. coli |
| Origin | Human |
| Conjugation | Unconjugated |
| Observed MW | Molecular Weight: Calculated MW: 22.8 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Gly65-Asn249 Tag: N-terminal His tag |
| Expression | Recombinant |
| Purity | > 95% |
| Size 1 | 10 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 500 µg |
| Form | Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex. |
| Tested Applications | WB, SDS-PAGE |
| Buffer | Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300. |
| Availability | Shipped within 5-12 working days. |
| Storage | Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q9NPH3 |
| Alias | C3orf13, IL-1R-3, IL-1R3, IL-1RAcP,IL1RAP,Interleukin-1 receptor 3,IL-1 receptor accessory protein,IL-1RAcP |
| Background | Protein IL1RAP |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
IL1RAP is a coreceptor that amplifies the interleukin-1 (IL-1) signaling cascade, which mediates inflammatory, immune, and stress responses. It forms a complex with the interleukin-1 receptor (IL-1R) and IL-1 ligand, facilitating the recruitment of the adaptor protein MyD88 and downstream activation of NF-κB, MAPK, and JNK pathways. These pathways lead to the transcription of pro-inflammatory cytokines, chemokines, and immune mediators critical for host defense. IL1RAP is widely expressed in immune cells such as monocytes, macrophages, dendritic cells, and T cells, playing pivotal roles in acute and chronic inflammatory responses, immune surveillance, and tissue repair. Beyond immunity, IL1RAP is overexpressed in cancers such as acute myeloid leukemia (AML) and solid tumors, where it enhances tumor proliferation and survival by supporting inflammatory microenvironments. Its role as a therapeutic target in inflammation and oncology is under investigation. Knockdown studies demonstrate impaired IL-1 signaling, reduced cytokine production, and weakened immune activation, underscoring its role as a crucial signaling scaffold in inflammation, immunity, and disease pathology.
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