Mouse Glucose-dependent insulinotropic receptor (GPR119) ELISA Kit
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935106861
info@markelab.com
Precio
715€ (96 tests)
Elisa kits for GPR119
proveedor
Abbexareference
abx525793Tested Applications
ELISAreactivity
Mousestatus
RUOclonality
Descripción
Mouse Glucose-dependent insulinotropic receptor (GPR119) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Mouse Glucose-dependent insulinotropic receptor concentrations in tissue homogenates, cell lysates and other biological fluids.
Background
GPR119 is a G protein-coupled receptor primarily expressed in pancreatic β-cells and enteroendocrine cells in the gastrointestinal tract. It is activated by endogenous lipids such as oleoylethanolamide (OEA) and dietary-derived fatty acid derivatives. GPR119 plays a critical role in glucose homeostasis and energy metabolism by stimulating glucose-dependent insulin secretion from pancreatic β-cells and promoting the release of incretin hormones like glucagon-like peptide-1 (GLP-1) and gastric inhibitory polypeptide (GIP) from intestinal cells. This dual action improves insulin sensitivity and regulates appetite, making GPR119 an attractive therapeutic target for type 2 diabetes and obesity. Activation of GPR119 leads to cAMP accumulation and downstream activation of insulinotropic pathways, enhancing glucose control without causing hypoglycemia. Dysregulation of GPR119 signaling has been associated with metabolic disorders, including insulin resistance and obesity. GPR119 agonists are currently being developed to improve glycemic control and promote weight loss, highlighting its significance in metabolic health.
Características del producto
category
ELISA Kits
immunogen target
Glucose-dependent insulinotropic receptor (GPR119)
reactivity
Mouse
test range
0.156 ng/ml - 10 ng/ml
assay data
Quantitative
form
Lyophilized
detection method
Colorimetric
sample type
Tissue homogenates, cell lysates and other biological fluids.
size 1
96 tests
alias
GPR119,GPCR2,glucose-dependent insulinotropic receptor,G-protein coupled receptor 2,G protein-coupled receptor 119
storage
Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual.
or code
GPR119
dry ice
No
uniprot id
note
This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.
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