Mouse Fibroblast Growth Factor Receptor Substrate 2 (FRS2) CLIA Kit
643.5€ (96 tests)
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name
Mouse Fibroblast Growth Factor Receptor Substrate 2 (FRS2) CLIA Kit
category
CLIA Kits
provider
Abbexa
reference
abx196951
tested applications
CLIA
Description
Mouse Fibroblast Growth Factor Receptor Substrate 2 (FRS2) Chemiluminescent Immunoassay (CLIA) Kit is a Chemiluminescent Immunoassay (CLIA) kit against Fibroblast Growth Factor Receptor Substrate 2 (FRS2).
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | CLIA Kits |
| Immunogen Target | Fibroblast Growth Factor Receptor Substrate 2 (FRS2) |
| Reactivity | Mouse |
| Detection Method | Chemiluminescent |
| Assay Data | Quantitative |
| Assay Type | Sandwich |
| Test Range | 3.13 pg/ml - 200 pg/ml |
| Sensitivity | 1.88 pg/ml |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 96 tests |
| Form | Lyophilized |
| Tested Applications | CLIA |
| Sample Type | Serum, plasma and other biological fluids. |
| Availability | Shipped within 5-12 working days. |
| Storage | Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| Alias | FRS2A, FRS2alpha, SNT, SNT-1, SNT1, FRS1A,FGFR substrate 2,FGFR-signaling adaptor SNT |
| Background | CLIA Kits FRS2 |
| Status | RUO |
| Note | The validity for this kit is 6 months. This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. |
Descripción
Fibroblast growth factor receptor substrate 2 (FRS2) is an intracellular adaptor protein that plays a pivotal role in the signaling pathways of fibroblast growth factor receptors (FGFRs). Upon FGFR activation, FRS2 becomes tyrosine-phosphorylated and acts as a docking platform for various signaling molecules. It primarily facilitates the recruitment of Grb2 and Sos, leading to the activation of the Ras/MAPK pathway, which is essential for cell proliferation, differentiation, and survival. FRS2 also interacts with Shp2, linking FGFR activation to the phosphatidylinositol 3-kinase (PI3K) pathway, which regulates cell survival and metabolic processes. FRS2 is highly involved in developmental processes and is often implicated in diseases such as cancer, where FGFR signaling is dysregulated. Its role as a signaling hub makes it a critical component in cellular communication and a potential target for therapeutic interventions in FGFR-related disorders.
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