Mouse Docking Protein 3 (DOK3) Protein

Este producto es parte de DOK - Docking protein
Mouse Docking Protein 3 (DOK3) Protein

Pida mas información

935106861

info@markelab.com

Precio

234€ (10 µg)

Protein DOK3

proveedor

Abbexa

reference

abx066359

Tested Applications

WB, SDS-PAGE

reactivity

status

RUO

clonality

Descripción

Recombinant Docking Protein 3 (DOK3) is a recombinant Mouse protein produced in a Prokaryotic expression system (E. coli).


Background

Docking protein 3 (DOK3) is a unique member of the DOK family, characterized by its selective expression in lymphoid tissues and its critical role in B-cell receptor (BCR) signaling. Unlike DOK1 and DOK2, DOK3 predominantly functions in modulating adaptive immune responses. It acts as a negative regulator of BCR signaling by interacting with various kinases and phosphatases, thereby preventing hyperactivation of B cells. This function is crucial for maintaining immune tolerance and preventing autoimmune disorders. DOK3 has also been implicated in the regulation of inflammation and the production of cytokines in macrophages. Dysregulation of DOK3 expression or function has been linked to immune deficiencies and certain lymphoid malignancies, highlighting its importance in immune regulation and cellular signaling pathways.

Características del producto

category

Proteins and Peptides


origin

Mouse


host

E. coli


immunogen target

Docking Protein 3 (DOK3)


host

E. coli


conjugation

Unconjugated


form

Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.


tested applications

WB, SDS-PAGE


size 1

10 µg


size 2

50 µg


size 3

100 µg


size 4

200 µg


size 5

500 µg


observerd MW

Molecular Weight: Calculated MW: 30.9 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Glu160-Glu409 Tag: N-terminal His tag


expression

Recombinant


purity

> 95%


buffer

Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300.


storage

Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.


or code

DOK3


dry ice

No


availability

Shipped within 5-7 working days.


alias

DOK3, DOKL, docking protein 3,Downstream of tyrosine kinase 3


note

This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use.


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