Docking Protein 3 (DOK3) Antibody
52€ (10 µg)
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935106861
info@markelab.com
name
Docking Protein 3 (DOK3) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx013670
tested applications
ELISA, WB
Description
Rabbit polyclonal antibody against DOK3 protein. Immunogen region is Internal.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Docking Protein 3 (DOK3) |
| Host | Rabbit |
| Reactivity | Human, Mouse |
| Recommended Dilution | WB: 1/500 - 1/3000, ELISA: 1/20000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified from rabbit antiserum by affinity chromatography using epitope-specific immunogen. |
| Size 1 | 10 µg |
| Size 2 | 100 µg |
| Size 3 | 200 µg |
| Size 4 | 300 µg |
| Size 5 | 1 mg |
| Form | Liquid |
| Tested Applications | ELISA, WB |
| Buffer | PBS (without Mg<sup>2+</sup> and Ca<sup>2+</sup>), pH 7.4, 150 mM NaCl, 0.02% sodium azide, 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q7L591 |
| Alias | DOK3, DOKL, docking protein 3,Downstream of tyrosine kinase 3 |
| Background | Antibody anti-DOK3 |
| Status | RUO |
| Note | Concentration: 1 mg/ml - |
Descripción
Docking protein 3 (DOK3) is a unique member of the DOK family, characterized by its selective expression in lymphoid tissues and its critical role in B-cell receptor (BCR) signaling. Unlike DOK1 and DOK2, DOK3 predominantly functions in modulating adaptive immune responses. It acts as a negative regulator of BCR signaling by interacting with various kinases and phosphatases, thereby preventing hyperactivation of B cells. This function is crucial for maintaining immune tolerance and preventing autoimmune disorders. DOK3 has also been implicated in the regulation of inflammation and the production of cytokines in macrophages. Dysregulation of DOK3 expression or function has been linked to immune deficiencies and certain lymphoid malignancies, highlighting its importance in immune regulation and cellular signaling pathways.
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