Mouse DENN domain-containing protein 2C (DENND2C) ELISA Kit

Este producto es parte de DENND - DENN domain containing
Mouse DENN domain-containing protein 2C (DENND2C) ELISA Kit

Pida mas información

935106861

info@markelab.com

Precio

715€ (96 tests)

Elisa kits for DENND2C

proveedor

Abbexa

reference

abx510097

Tested Applications

ELISA

reactivity

Mouse

status

RUO

clonality

Descripción

Mouse DENN domain-containing protein 2C (DENND2C) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Mouse DENN domain-containing protein 2C concentrations in serum, plasma, tissue homogenates, cell culture supernatants and other biological fluids.


Background

DENN domain containing 2C (DENND2C) acts as a guanine nucleotide exchange factor (GEF) for Rab GTPases, regulating intracellular vesicle trafficking and membrane dynamics. DENND2C activates Rab9 by facilitating the exchange of GDP for GTP, enabling vesicular transport between late endosomes and the trans-Golgi network. This activity is essential for the sorting and trafficking of lysosomal enzymes and other cargo, maintaining cellular proteostasis. In addition to its role in endosomal transport, DENND2C contributes to signaling pathways that depend on membrane trafficking, including those involved in cell growth and stress responses. DENND2C is expressed in various tissues, but its activity is particularly significant in cells with high lysosomal turnover, such as macrophages and epithelial cells. Dysregulation of DENND2C has been linked to diseases involving lysosomal dysfunction, highlighting its importance in cellular homeostasis and adaptive responses.

Características del producto

category

ELISA Kits


immunogen target

DENN domain-containing protein 2C (DENND2C)


reactivity

Mouse


test range

0.156 ng/ml - 10 ng/ml


assay data

Quantitative


form

Lyophilized


detection method

Colorimetric


sample type

Serum, plasma, tissue homogenates, cell culture supernatants and other biological fluids.


size 1

96 tests


alias

dJ1156J9.1


storage

Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual.


or code

DENND2C


dry ice

No


note

This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.


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