Mouse DENN domain-containing protein 2C (DENND2C) ELISA Kit
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Pida mas información
935106861
info@markelab.com
Precio
715€ (96 tests)
Elisa kits for DENND2C
proveedor
Abbexareference
abx510097Tested Applications
ELISAreactivity
Mousestatus
RUOclonality
Descripción
Mouse DENN domain-containing protein 2C (DENND2C) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Mouse DENN domain-containing protein 2C concentrations in serum, plasma, tissue homogenates, cell culture supernatants and other biological fluids.
Background
DENN domain containing 2C (DENND2C) acts as a guanine nucleotide exchange factor (GEF) for Rab GTPases, regulating intracellular vesicle trafficking and membrane dynamics. DENND2C activates Rab9 by facilitating the exchange of GDP for GTP, enabling vesicular transport between late endosomes and the trans-Golgi network. This activity is essential for the sorting and trafficking of lysosomal enzymes and other cargo, maintaining cellular proteostasis. In addition to its role in endosomal transport, DENND2C contributes to signaling pathways that depend on membrane trafficking, including those involved in cell growth and stress responses. DENND2C is expressed in various tissues, but its activity is particularly significant in cells with high lysosomal turnover, such as macrophages and epithelial cells. Dysregulation of DENND2C has been linked to diseases involving lysosomal dysfunction, highlighting its importance in cellular homeostasis and adaptive responses.
Características del producto
category
ELISA Kits
immunogen target
DENN domain-containing protein 2C (DENND2C)
reactivity
Mouse
test range
0.156 ng/ml - 10 ng/ml
assay data
Quantitative
form
Lyophilized
detection method
Colorimetric
sample type
Serum, plasma, tissue homogenates, cell culture supernatants and other biological fluids.
size 1
96 tests
alias
dJ1156J9.1
storage
Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual.
or code
DENND2C
dry ice
No
uniprot id
note
This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.
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