Mouse DENN domain-containing protein 1B (DENND1B) ELISA Kit

Product specifications

ELISA Kits

DENN domain-containing protein 1B (DENND1B)

Mouse

Colorimetric

Quantitative

0.156 ng/ml - 10 ng/ml

Optimal dilutions/concentrations should be determined by the end user.

96 tests

Lyophilized

ELISA

Tissue homogenates, cell lysates and other biological fluids.

Shipped within 5-15 working days. The validity for this kit is 6 months.

Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual.

No

Q3U1T9

329260

FAM31B,C1ORF18,C1orf218,Protein FAM31B,

Elisa kits for DENND1B

RUO

Validity: The validity for this kit is 6 months.

This product is for research use only.   The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments.   Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.

Descripción

DENN domain containing 1B (DENND1B) is a member of the DENN domain protein family, serving as a guanine nucleotide exchange factor (GEF) for Rab GTPases, specifically activating Rab35. Through its conserved DENN domain, DENND1B regulates endosomal trafficking and recycling processes, ensuring the sorting, transport, and fusion of vesicles within the endosomal system. It plays a critical role in cytokinesis by facilitating plasma membrane recycling and the proper separation of daughter cells during cell division. DENND1B is also implicated in immune cell signaling, where it contributes to cytokine secretion and receptor recycling in inflammatory responses. Dysregulation of DENND1B has been linked to increased susceptibility to inflammatory diseases, including asthma, due to its role in controlling immune signaling pathways. Its expression in immune-related tissues underscores its importance in coordinating immune cell responses and maintaining intracellular transport mechanisms. DENND1B also interacts with other Rab GTPases, further emphasizing its versatility in regulating vesicular dynamics and membrane remodeling.

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