DENN Domain-Containing Protein 1B (DENND1B) Antibody
357.5€ (100 µg)
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935106861
info@markelab.com
name
DENN Domain-Containing Protein 1B (DENND1B) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx145430
tested applications
ELISA, WB, IHC
Description
DENND1B Antibody is a Rabbit Polyclonal against DENND1B.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | DENN Domain-Containing Protein 1B (DENND1B) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | ELISA: 1/20000 - 1/80000, WB: 1/500 - 1/2000, IHC: 1/100 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified by antigen affinity column chromatography. |
| Size 1 | 100 µg |
| Size 2 | 1 mg |
| Form | Lyophilized |
| Tested Applications | ELISA, WB, IHC |
| Buffer | Prior to lyophilization: 1% BSA and 0.02% NaN3. |
| Availability | Shipped within 7-15 working days. |
| Storage | Store at -20 °C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| NCBI Accession | BC022561 |
| Alias | FAM31B,C1ORF18,C1orf218,Protein FAM31B, |
| Background | Antibody anti-DENND1B |
| Status | RUO |
| Note | Concentration: Lyophilized form: Not applicable. After reconstitution: 1 mg/ml. - |
Descripción
DENN domain containing 1B (DENND1B) is a member of the DENN domain protein family, serving as a guanine nucleotide exchange factor (GEF) for Rab GTPases, specifically activating Rab35. Through its conserved DENN domain, DENND1B regulates endosomal trafficking and recycling processes, ensuring the sorting, transport, and fusion of vesicles within the endosomal system. It plays a critical role in cytokinesis by facilitating plasma membrane recycling and the proper separation of daughter cells during cell division. DENND1B is also implicated in immune cell signaling, where it contributes to cytokine secretion and receptor recycling in inflammatory responses. Dysregulation of DENND1B has been linked to increased susceptibility to inflammatory diseases, including asthma, due to its role in controlling immune signaling pathways. Its expression in immune-related tissues underscores its importance in coordinating immune cell responses and maintaining intracellular transport mechanisms. DENND1B also interacts with other Rab GTPases, further emphasizing its versatility in regulating vesicular dynamics and membrane remodeling.
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