Mouse Dedicator of cytokinesis protein 4 (DOCK4) ELISA Kit
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935106861
info@markelab.com
Precio
715€ (96 tests)
Elisa kits for DOCK4
proveedor
Abbexareference
abx510794Tested Applications
ELISAreactivity
Mousestatus
RUOclonality
Descripción
Mouse Dedicator of cytokinesis protein 4 (DOCK4) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Mouse Dedicator of cytokinesis protein 4 concentrations in tissue homogenates, cell lysates and other biological fluids.
Background
DOCK4 is a GEF that activates Rac1 and Rap1, regulating cell adhesion, migration, and junction formation. It is critical for maintaining epithelial integrity and angiogenesis by promoting actin cytoskeletal remodeling. DOCK4 is widely expressed in tissues, including the brain, and has roles in neuronal development, synapse formation, and dendritic growth. Mutations in DOCK4 are linked to cancers, particularly prostate, ovarian, and colorectal cancers, as they disrupt cell adhesion and enhance invasion. It interacts with proteins like ELMO1 for Rac1 activation and mediates processes such as cell spreading. Knockdown studies show impaired junction stability and migration, emphasizing its role in tissue organization and metastasis.
Características del producto
category
ELISA Kits
immunogen target
Dedicator of cytokinesis protein 4 (DOCK4)
reactivity
Mouse
test range
0.156 ng/ml - 10 ng/ml
assay data
Quantitative
form
Lyophilized
detection method
Colorimetric
sample type
Tissue homogenates, cell lysates and other biological fluids.
size 1
96 tests
alias
DOCK4, KIAA0716
storage
Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual.
or code
DOCK4
dry ice
No
uniprot id
note
This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.
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