Human Dedicator Of Cytokinesis 4 (DOCK4) Protein

Este producto es parte de DOCK - Dedicator of Cytokinesis
Human Dedicator Of Cytokinesis 4 (DOCK4) Protein

Pida mas información

935106861

info@markelab.com

Precio

221€ (10 µg)

Protein DOCK4

proveedor

Abbexa

reference

abx168105

Tested Applications

WB, SDS-PAGE

reactivity

status

RUO

clonality

Descripción

Human Dedicator Of Cytokinesis 4 Protein is a recombinant Human protein expressed in E. coli.


Background

DOCK4 is a GEF that activates Rac1 and Rap1, regulating cell adhesion, migration, and junction formation. It is critical for maintaining epithelial integrity and angiogenesis by promoting actin cytoskeletal remodeling. DOCK4 is widely expressed in tissues, including the brain, and has roles in neuronal development, synapse formation, and dendritic growth. Mutations in DOCK4 are linked to cancers, particularly prostate, ovarian, and colorectal cancers, as they disrupt cell adhesion and enhance invasion. It interacts with proteins like ELMO1 for Rac1 activation and mediates processes such as cell spreading. Knockdown studies show impaired junction stability and migration, emphasizing its role in tissue organization and metastasis.

Características del producto

category

Proteins and Peptides


origin

Human


host

E. coli


immunogen target

Dedicator Of Cytokinesis 4 (DOCK4)


host

E. coli


conjugation

Unconjugated


form

Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.


tested applications

WB, SDS-PAGE


size 1

10 µg


size 2

50 µg


size 3

100 µg


size 4

200 µg


size 5

500 µg


observerd MW

Molecular Weight: Calculated MW: 38.7 kDa Observed MW (SDS-PAGE): 39 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Met1-Pro300 Tag: N-terminal His tag


expression

Recombinant


purity

> 90%


buffer

Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300.


storage

Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.


or code

DOCK4


dry ice

No


availability

Shipped within 5-7 working days.


alias

DOCK4, KIAA0716


note

This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use.


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