Dedicator of Cytokinesis 4 (DOCK4) Antibody
286€ (100 µl)
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935106861
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name
Dedicator of Cytokinesis 4 (DOCK4) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx129252
tested applications
WB, IHC
Description
Dedicator Of Cytokinesis 4 Antibody is a Rabbit Polyclonal against Dedicator Of Cytokinesis 4.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Dedicator of Cytokinesis 4 (DOCK4) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | WB: 0.01-2 µg/ml, IHC: 5-20 µg/ml. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Purification | Purified by antigen-specific affinity chromatography, followed by Protein A affinity chromatography. |
| Size 1 | 100 µl |
| Size 2 | 200 µl |
| Size 3 | 1 ml |
| Form | Liquid |
| Tested Applications | WB, IHC |
| Buffer | 0.01 M PBS, pH 7.4, containing 0.05% Proclin-300, 50% glycerol. |
| Availability | Shipped within 5-7 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q8N1I0 |
| Gene ID | 9732 |
| OMIM | 607679 |
| Alias | DOCK4, KIAA0716 |
| Background | Antibody anti-DOCK4 |
| Status | RUO |
| Note | Concentration: 0.5 mg/ml - |
Descripción
DOCK4 is a GEF that activates Rac1 and Rap1, regulating cell adhesion, migration, and junction formation. It is critical for maintaining epithelial integrity and angiogenesis by promoting actin cytoskeletal remodeling. DOCK4 is widely expressed in tissues, including the brain, and has roles in neuronal development, synapse formation, and dendritic growth. Mutations in DOCK4 are linked to cancers, particularly prostate, ovarian, and colorectal cancers, as they disrupt cell adhesion and enhance invasion. It interacts with proteins like ELMO1 for Rac1 activation and mediates processes such as cell spreading. Knockdown studies show impaired junction stability and migration, emphasizing its role in tissue organization and metastasis.
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