Mouse Death Domain Associated Protein / DAP6 (DAXX) ELISA Kit

Este producto es parte de DAXX - Death-associated protein 6
Mouse Death Domain Associated Protein / DAP6 (DAXX) ELISA Kit
715€ (96 tests)

Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.

Name
Mouse Death Domain Associated Protein / DAP6 (DAXX) ELISA Kit
Category
ELISA Kits
Provider
Abbexa
Reference
abx352659
Tested Applications
ELISA

Description

Mouse Death Domain Associated Protein / DAP6 (DAXX) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Mouse Death Associated Protein 6 concentrations in tissue homogenates, cell lysates and other biological fluids.

Documentos del producto

Instrucciones
Data sheet
Descargar

Especificaciones del producto

Category
ELISA Kits
Immunogen Target
Death Domain Associated Protein / DAP6 (DAXX)
Reactivity
Mouse
Detection Method
Colorimetric
Assay Data
Quantitative
Assay Type
Sandwich
Test Range
0.78 ng/ml - 50 ng/ml
Sensitivity
0.47 ng/ml
Recommended Dilution
Optimal dilutions/concentrations should be determined by the end user.
Size 1
96 tests
Size 2
5 × 96 tests
Size 3
10 × 96 tests
Form
Standard Form: Lyophilized
Tested Applications
ELISA
Sample Type
Tissue homogenates, cell lysates and other biological fluids.
Availability
Shipped within 5-7 working days.
Storage
Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual.
Dry Ice
No
UniProt ID
O35613
Gene ID
13163
Alias
DAXX, BING2, DAP6, EAP1, death-domain associated protein, death domain associated protein, SMIM40
Background
Elisa Kits for: DAXX
Status
RUO
Note
THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.
The stability of the kit is determined by the rate of activity loss. The loss rate is less than 5% within the expiration date under appropriate storage conditions. To minimize performance fluctuations, operation procedures and lab conditions should be strictly controlled. It is also strongly suggested that the whole assay is performed by the same user throughout.

Background

Death-Associated Protein 6 (DAXX) is a multifunctional protein involved in apoptosis regulation, transcriptional control, and chromatin remodeling. Initially identified as a Fas-binding protein, DAXX can mediate apoptotic signals in response to Fas receptor activation, playing a role in programmed cell death. In addition to its role in apoptosis, DAXX functions as a transcriptional co-repressor, interacting with various transcription factors to modulate gene expression. DAXX is also a key component of the chromatin remodeling machinery, where it interacts with histone chaperones and contributes to histone deposition and nucleosome assembly. It is localized to promyelocytic leukemia nuclear bodies (PML-NBs) and telomeres, where it participates in DNA damage responses and telomere maintenance. Dysregulation of DAXX is linked to cancer, as it can act as a tumor suppressor or promoter depending on the cellular context. Mutations in DAXX are frequently observed in pancreatic neuroendocrine tumors and other cancers, where they contribute to genomic instability and altered gene expression. DAXX is being investigated as a therapeutic target due to its diverse roles in apoptosis, chromatin dynamics, and tumorigenesis.

Productos relacionados

abx010630

Death Domain Associated Protein / DAP6 (DAXX) Antibody

Daxx is a transcriptional co-regulatory protein. Proposed to mediate activation of the JNK pathway and apoptosis via ASK…

Ver producto
abx031856

DAXX (pS213) Antibody

DAXX is proposed to mediate activation of the JNK pathway and apoptosis via MAP3K5 in response to signaling from TNFRSF6…

Ver producto
abx032021

DAXX (pS671) Antibody

This product is currently in development. The lead time for this product may be several months. Please contact us at…

Ver producto