Daxx is a transcriptional co-regulatory protein. Proposed to mediate activation of the JNK pathway and apoptosis via ASK1 in response to signaling from FAS and TGF beta R2. Glucose deprivation activates the ASK1-SEK1-JNK1-HIPK1 pathway, relocalizing Daxx from the nucleus to the cytoplasm, where Daxx binds to ASK1, and subsequently leads to ASK1 oligomerization. Interaction with HSP27 may prevent interaction with TGF beta R2 and ASK1 and block DAXX-mediated apoptosis. Seems to act as a transcriptional co- repressor and inhibits PAX3 and ETS1 through direct protein- protein interaction. Its transcription repressor activity is modulated by recruiting it to subnuclear compartments like the nucleolus or PML/POD/ND10 nuclear bodies through interactions with MCSR1 and PML, respectively. Two alternatively spliced isoforms have been described.
Primary Antibodies
Monoclonal
Human
Death Domain Associated Protein / DAP6 (DAXX)
Mouse
Unconjugated
Liquid
ELISA, WB, IF/ICC, FCM
Unpurified ascites.
Ascitic fluid containing 0.03% sodium azide.
100 µl
Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
DAXX
No
Shipped within 5-10 working days.
DAXX, BING2, DAP6, EAP1, death-domain associated protein, death domain associated protein, SMIM40
This product is for research use only.
Transcription corepressor known to repress transcriptional potential of several sumoylated transcription factors. Down-r...
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