DAXX (pS671) Antibody

Documentos del producto

Especificaciones del producto

Primary Antibodies

Target: DAXX (pS671)
Immunogen: KLH-conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S671 of human DAXX.

Rabbit

Human

DB: 1/500. Optimal dilutions/concentrations should be determined by the end user.

Polyclonal

Unconjugated

IgG

Calculated MW: 81.4 kDa

Purified through a protein A column, followed by two-step phosphospecific peptide affinity purification.

80 µl

400 µl

Liquid

ELISA, DB

PBS containing 0.09% sodium azide.

Please enquire.

Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.

No

Q9UER7

DAXX, BING2, DAP6, EAP1, death-domain associated protein, death domain associated protein, SMIM40

Antibody anti-DAXX

RUO

THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION.

Background

Death-Associated Protein 6 (DAXX) is a multifunctional protein involved in apoptosis regulation, transcriptional control, and chromatin remodeling. Initially identified as a Fas-binding protein, DAXX can mediate apoptotic signals in response to Fas receptor activation, playing a role in programmed cell death. In addition to its role in apoptosis, DAXX functions as a transcriptional co-repressor, interacting with various transcription factors to modulate gene expression. DAXX is also a key component of the chromatin remodeling machinery, where it interacts with histone chaperones and contributes to histone deposition and nucleosome assembly. It is localized to promyelocytic leukemia nuclear bodies (PML-NBs) and telomeres, where it participates in DNA damage responses and telomere maintenance. Dysregulation of DAXX is linked to cancer, as it can act as a tumor suppressor or promoter depending on the cellular context. Mutations in DAXX are frequently observed in pancreatic neuroendocrine tumors and other cancers, where they contribute to genomic instability and altered gene expression. DAXX is being investigated as a therapeutic target due to its diverse roles in apoptosis, chromatin dynamics, and tumorigenesis.

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