Mouse Corticotropin Releasing Hormone Receptor 2 (CRHR2) ELISA Kit

Product specifications

ELISA Kits

Corticotropin Releasing Hormone Receptor 2 (CRHR2)

Mouse

Colorimetric

Quantitative

Sandwich

0.312 ng/ml - 20 ng/ml

< 0.161 ng/ml

Optimal dilutions/concentrations should be determined by the end user.

96 tests

Lyophilized

ELISA

Tissue homogenates, cell lysates and other biological fluids.

Shipped within 5-12 working days. The validity for this kit is 6 months.

Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual.

No

Q60748

CRHR2,CRFR2,CRF-R2,CRH-R2,CRF 2 receptor,CRFR2alpha,CRFR2beta,CRF2,CRF-RB,HM-CRF

Elisa kits for CRHR2

RUO

Validity: The validity for this kit is 6 months.
This product is for research use only.   The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments.   Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.

Descripción

CRHR2 is a G protein-coupled receptor that binds CRH and urocortins (urocortin 2 and urocortin 3), with roles in modulating stress responses, cardiovascular function, and energy homeostasis. CRHR2 is expressed in peripheral tissues, including the heart, gastrointestinal tract, and vasculature, as well as in specific brain regions such as the hypothalamus and brainstem. Unlike CRHR1, CRHR2 is more involved in stress recovery and adaptation, mediating anti-stress effects by regulating heart rate, vascular tone, and feeding behaviors. CRHR2 activation triggers signaling pathways such as cAMP/PKA and MAPK, which regulate cell proliferation, relaxation of smooth muscle, and metabolic homeostasis. It plays a protective role in cardiovascular function, where its activation reduces blood pressure and cardiac stress. CRHR2 is also involved in regulating appetite suppression and energy expenditure, making it a potential target for obesity and metabolic disorders. Dysregulation of CRHR2 has been linked to stress-related disorders, heart disease, and gastrointestinal dysfunction. In cancer, CRHR2 may modulate tumor progression through its effects on angiogenesis and stress pathways. CRHR2 agonists and antagonists are under investigation for their therapeutic potential in cardiovascular disease, metabolic dysfunctions, and stress-related psychiatric disorders, highlighting its role in recovery from physiological and psychological stress.

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