CRHR2 antibody
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Name
CRHR2 antibody
Category
Primary Antibodies
Provider
FineTest
Reference
FNab01975
Tested Applications
ELISA, WB, IHC
Description
G-protein coupled receptor for CRH(corticotropin-releasing factor), UCN(urocortin), UCN2 and UCN3. Has high affinity for UCN. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins(G proteins) and down-stream effectors, such as adenylate cyclase. Promotes the activation of adenylate cyclase, leading to increased intracellular cAMP levels.
Documentos del producto
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | corticotropin releasing hormone receptor 2 (CRHR2) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | WB: 1:500 - 1:2000; IHC: 1:50 - 1:100 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | 56 kDa |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, WB, IHC |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| UniProt ID | Q13324 |
| Gene ID | 1395 |
| Alias | CRHR2,CRFR2,CRF-R2,CRH-R2,CRF 2 receptor,CRFR2alpha,CRFR2beta,CRF2,CRF-RB,HM-CRF |
| Background | Antibody anti-CRHR2 |
| Status | RUO |
| Note | Mol. Weight 56 kDa |
Background
CRHR2 is a G protein-coupled receptor that binds CRH and urocortins (urocortin 2 and urocortin 3), with roles in modulating stress responses, cardiovascular function, and energy homeostasis. CRHR2 is expressed in peripheral tissues, including the heart, gastrointestinal tract, and vasculature, as well as in specific brain regions such as the hypothalamus and brainstem. Unlike CRHR1, CRHR2 is more involved in stress recovery and adaptation, mediating anti-stress effects by regulating heart rate, vascular tone, and feeding behaviors. CRHR2 activation triggers signaling pathways such as cAMP/PKA and MAPK, which regulate cell proliferation, relaxation of smooth muscle, and metabolic homeostasis. It plays a protective role in cardiovascular function, where its activation reduces blood pressure and cardiac stress. CRHR2 is also involved in regulating appetite suppression and energy expenditure, making it a potential target for obesity and metabolic disorders. Dysregulation of CRHR2 has been linked to stress-related disorders, heart disease, and gastrointestinal dysfunction. In cancer, CRHR2 may modulate tumor progression through its effects on angiogenesis and stress pathways. CRHR2 agonists and antagonists are under investigation for their therapeutic potential in cardiovascular disease, metabolic dysfunctions, and stress-related psychiatric disorders, highlighting its role in recovery from physiological and psychological stress.
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