Mouse Contactin 6 (CNTN6) Protein
234€ (10 µg)
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935106861
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name
Mouse Contactin 6 (CNTN6) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx168406
tested applications
WB, SDS-PAGE
Description
Mouse Contactin 6 Protein is a recombinant Mouse protein expressed in E. coli.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | Contactin 6 (CNTN6) |
| Host | E. coli |
| Assay Type | Activity: Not tested Sequence Fragment: Tyr658-Pro907 Tag: N-terminal His tag |
| Origin | Mouse |
| Conjugation | Unconjugated |
| Observed MW | Calculated MW: 30.8 kDa |
| Expression | Recombinant |
| Purity | > 95% |
| Size 1 | 10 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 500 µg |
| Form | Lyophilized |
| Tested Applications | WB, SDS-PAGE |
| Buffer | Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300. |
| Availability | Shipped within 5-7 working days. |
| Storage | Store lyophilized form at 2-8°C for up to 1 month. For longer periods, store lyophilized or liquid at -80°C. Avoid repeated freeze–thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q9JMB8 |
| Alias | NB3,Neural recognition molecule NB-3,hNB-3,Contactin-6 |
| Background | Protein CNTN6 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex. Concentration: Prior to lyophilization: 200 µg/ml |
Descripción
Contactin 6 (CNTN6), also referred to as NB-3, is a neuronal cell adhesion molecule that is highly expressed in the brain and spinal cord during development. It regulates axon guidance, neuronal migration, and synapse formation, particularly in corticospinal tract development and cerebellar circuit organization. CNTN6 interacts with other contactins and neural receptors to facilitate synaptic connectivity and plasticity, contributing to the establishment of neural networks involved in motor control and coordination. Genetic studies have implicated CNTN6 in neurodevelopmental disorders such as autism spectrum disorders (ASD) and intellectual disability, where its dysregulation disrupts neuronal connectivity and cognitive functions. In addition to its roles in development, CNTN6 expression persists in the adult nervous system, suggesting ongoing functions in synaptic maintenance and plasticity. Structurally, CNTN6 features extracellular immunoglobulin-like and fibronectin type III domains, which mediate its adhesive and signaling interactions. Emerging research also highlights its potential involvement in neuropathological conditions, including neurodegenerative diseases and peripheral neuropathies.
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