Mouse Contactin 1 (CNTN1) Protein
1079€ (100 µg)
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935106861
info@markelab.com
name
Mouse Contactin 1 (CNTN1) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx691866
tested applications
SDS-PAGE
Description
Mouse Contactin 1 Protein is a recombinant protein from Mouse produced in HEK293 Cells. A DNA sequence encoding the mouse CNTN1 (NP_031753.1) (Met1-Leu1000) was expressed with a C-terminal polyhistidine tag.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | Contactin 1 |
| Host | HEK293 cells |
| Origin | Mouse |
| Observed MW | Molecular Weight: 110.5 kDa Sequence Fragment: Met1-Leu1000 Tag: C-terminal His tag Validity: The validity for this protein is 12 months. |
| Expression | Recombinant |
| Purity | > 90% (SDS-PAGE) |
| Size 1 | 100 µg |
| Form | |
| Tested Applications | SDS-PAGE |
| Buffer | Lyophilized from sterile PBS, pH 7.4. |
| Availability | Shipped within 5-15 working days. |
| Storage | Aliquot and store at -20°C or -80°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| NCBI Accession | NP_031753.1 |
| Alias | F3,GP135,MYPCN,CMYP12,Neural cell surface protein F3,Glycoprotein gp135,Contactin-1 |
| Background | Protein CNTN1 |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
Contactin 1 (CNTN1) is a neuronal cell adhesion molecule belonging to the immunoglobulin superfamily, playing a crucial role in nervous system development and maintenance. CNTN1 is a glycosylphosphatidylinositol (GPI)-anchored protein predominantly expressed in neurons, where it mediates axon guidance, neuronal migration, and synaptic formation. It interacts with other cell surface receptors such as the Notch and amyloid precursor protein (APP) signaling pathways, influencing neuronal differentiation and axon pathfinding. CNTN1 is also involved in the formation and stabilization of paranodal junctions in myelinated nerves by binding to Caspr and neurofascin, ensuring proper saltatory conduction. Dysregulation of CNTN1 has been implicated in neurodevelopmental disorders such as autism spectrum disorders (ASD) and intellectual disabilities, as well as in autoimmune neuropathies like chronic inflammatory demyelinating polyneuropathy (CIDP). It has also been linked to cancer metastasis, with elevated levels associated with poor prognosis in certain tumors. Its extracellular immunoglobulin-like and fibronectin type III domains mediate homophilic and heterophilic interactions, making it an essential player in neuronal connectivity and signaling.
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