Contactin 1 (CNTN1) Antibody
292.5€ (80 µl)
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935106861
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name
Contactin 1 (CNTN1) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx034394
tested applications
ELISA, WB
Description
CNTN1 is a member of the immunoglobulin superfamily. It is a glycosylphosphatidylinositol (GPI) anchored neuronal membrane protein that functions as a cell adhesion molecule. It may play a role in the formation of axon connections in the developing nervous system.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Contactin 1 (CNTN1) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | WB: 1/1000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified through a protein A column, followed by peptide affinity purification. |
| Size 1 | 80 µl |
| Size 2 | 400 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB |
| Buffer | PBS containing 0.09% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q12860 |
| Alias | F3,GP135,MYPCN,CMYP12,Neural cell surface protein F3,Glycoprotein gp135,Contactin-1 |
| Background | Antibody anti-CNTN1 |
| Status | RUO |
Descripción
Contactin 1 (CNTN1) is a neuronal cell adhesion molecule belonging to the immunoglobulin superfamily, playing a crucial role in nervous system development and maintenance. CNTN1 is a glycosylphosphatidylinositol (GPI)-anchored protein predominantly expressed in neurons, where it mediates axon guidance, neuronal migration, and synaptic formation. It interacts with other cell surface receptors such as the Notch and amyloid precursor protein (APP) signaling pathways, influencing neuronal differentiation and axon pathfinding. CNTN1 is also involved in the formation and stabilization of paranodal junctions in myelinated nerves by binding to Caspr and neurofascin, ensuring proper saltatory conduction. Dysregulation of CNTN1 has been implicated in neurodevelopmental disorders such as autism spectrum disorders (ASD) and intellectual disabilities, as well as in autoimmune neuropathies like chronic inflammatory demyelinating polyneuropathy (CIDP). It has also been linked to cancer metastasis, with elevated levels associated with poor prognosis in certain tumors. Its extracellular immunoglobulin-like and fibronectin type III domains mediate homophilic and heterophilic interactions, making it an essential player in neuronal connectivity and signaling.
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