Mouse Chemokine C-X-C-Motif Receptor 3 (CXCR3) Protein
1872€ (1 mg)
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935106861
info@markelab.com
name
Mouse Chemokine C-X-C-Motif Receptor 3 (CXCR3) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx652881
tested applications
WB, SDS-PAGE
Description
Mouse Chemokine C-X-C-Motif Receptor 3 (CXCR3) Protein is a Recombinant Mouse protein expressed in E. coli.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | Chemokine C-X-C-Motif Receptor 3 (CXCR3) |
| Host | E. coli |
| Origin | Mouse |
| Conjugation | Unconjugated |
| Observed MW | Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Please enquire. Tag: N-terminal His tag |
| Expression | Recombinant |
| Purity | > 90% |
| Size 1 | 1 mg |
| Size 2 | 5 mg |
| Form | Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex. |
| Tested Applications | WB, SDS-PAGE |
| Buffer | Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300. |
| Availability | Shipped within 1-2 months. |
| Storage | Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| Alias | CXCR3,GPR9,MigR,CD182,CD183,Mig-R,CKR-L2,CMKAR3,IP10-R,G protein-coupled receptor 9,CXC-R3,interferon-inducible protein 10 receptor,IP-10 receptor |
| Background | Protein CXCR3 |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
CXCR3 is a G protein-coupled receptor (GPCR) primarily expressed on activated T cells, natural killer (NK) cells, and some epithelial cells. It binds chemokines such as CXCL9, CXCL10, and CXCL11, which are induced by interferon-gamma during inflammation. CXCR3 plays a critical role in T cell trafficking, promoting migration to inflammatory sites and tumor microenvironments. Its activation triggers signaling pathways like PI3K, MAPK, and JAK/STAT, leading to cell migration, proliferation, and cytokine production. CXCR3 has two main isoforms, CXCR3-A and CXCR3-B, which mediate different functions: CXCR3-A drives chemotaxis and immune cell recruitment, while CXCR3-B can induce apoptosis and inhibit cell migration under specific conditions. CXCR3 is implicated in autoimmune diseases like rheumatoid arthritis, multiple sclerosis, and inflammatory bowel disease, where aberrant T cell migration leads to chronic inflammation. In cancer, CXCR3 regulates both pro- and anti-tumor responses; while it facilitates immune cell infiltration into tumors, it can also enhance tumor cell metastasis and angiogenesis in some cancers. Its expression in tumor cells has been linked to poor prognosis, particularly in melanoma, breast, and lung cancers. Pharmacological targeting of CXCR3 is being explored to modulate immune responses, reduce inflammation, and improve cancer immunotherapy. Overall, CXCR3 is essential for immune cell migration, balancing immune surveillance and disease progression.
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