Chemokine C-X-C-Motif Receptor 3 (CXCR3) Antibody
52€ (10 µg)
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935106861
info@markelab.com
name
Chemokine C-X-C-Motif Receptor 3 (CXCR3) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx119624
tested applications
WB
Description
CXCR3 Antibody is a Rabbit Polyclonal antibody against CXCR3.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Chemokine C-X-C-Motif Receptor 3 (CXCR3) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified from rabbit antiserum by affinity chromatography using epitope-specific immunogen. |
| Size 1 | 10 µg |
| Size 2 | 100 µg |
| Size 3 | 200 µg |
| Size 4 | 300 µg |
| Size 5 | 1 mg |
| Form | Liquid |
| Tested Applications | WB |
| Buffer | PBS (without Mg<sup>2+</sup> and Ca<sup>2+</sup>), pH 7.4, 150 mM NaCl, 0.02% sodium azide, 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P49682 |
| Alias | CXCR3,GPR9,MigR,CD182,CD183,Mig-R,CKR-L2,CMKAR3,IP10-R,G protein-coupled receptor 9,CXC-R3,interferon-inducible protein 10 receptor,IP-10 receptor |
| Background | Antibody anti-CXCR3 |
| Status | RUO |
| Note | Concentration: 1 mg/ml - |
Descripción
CXCR3 is a G protein-coupled receptor (GPCR) primarily expressed on activated T cells, natural killer (NK) cells, and some epithelial cells. It binds chemokines such as CXCL9, CXCL10, and CXCL11, which are induced by interferon-gamma during inflammation. CXCR3 plays a critical role in T cell trafficking, promoting migration to inflammatory sites and tumor microenvironments. Its activation triggers signaling pathways like PI3K, MAPK, and JAK/STAT, leading to cell migration, proliferation, and cytokine production. CXCR3 has two main isoforms, CXCR3-A and CXCR3-B, which mediate different functions: CXCR3-A drives chemotaxis and immune cell recruitment, while CXCR3-B can induce apoptosis and inhibit cell migration under specific conditions. CXCR3 is implicated in autoimmune diseases like rheumatoid arthritis, multiple sclerosis, and inflammatory bowel disease, where aberrant T cell migration leads to chronic inflammation. In cancer, CXCR3 regulates both pro- and anti-tumor responses; while it facilitates immune cell infiltration into tumors, it can also enhance tumor cell metastasis and angiogenesis in some cancers. Its expression in tumor cells has been linked to poor prognosis, particularly in melanoma, breast, and lung cancers. Pharmacological targeting of CXCR3 is being explored to modulate immune responses, reduce inflammation, and improve cancer immunotherapy. Overall, CXCR3 is essential for immune cell migration, balancing immune surveillance and disease progression.
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