Mouse Caspase Recruitment Domain Family, Member 9 (CARD9) Protein
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Description
Recombinant Caspase Recruitment Domain Family, Member 9 (CARD9) is a recombinant Mouse protein produced in a Prokaryotic expression system (E. coli).
Documents del producto
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | Caspase Recruitment Domain Family, Member 9 (CARD9) |
| Host | E. coli |
| Origin | Mouse |
| Conjugation | Unconjugated |
| Observed MW | Molecular Weight: Calculated MW: 33.8 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Asp274-Asn530 Tag: N-terminal His tag |
| Expression | Recombinant |
| Purity | > 95% |
| Size 1 | 10 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 500 µg |
| Form | Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex. |
| Tested Applications | WB, SDS-PAGE |
| Buffer | Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300. |
| Availability | Shipped within 5-7 working days. |
| Storage | Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | A2AIV8 |
| Alias | CARD9, CANDF2,Hcard9,IMD103 |
| Background | Protein CARD9 |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
CARD9 is a key protein in the immune response, particularly in the signaling pathways of innate immunity. It is involved in activating the NF-κB signaling pathway, which plays a crucial role in inflammation and immune cell activation. CARD9 acts as an adaptor protein that connects pattern recognition receptors, such as C-type lectin receptors (CLRs), to downstream signaling pathways. This enables the recognition of microbial pathogens and triggers an immune response. Specifically, CARD9 is important in the recognition of fungal and bacterial infections, where it contributes to the activation of inflammatory cytokines and the recruitment of immune cells. Mutations or deficiencies in CARD9 can lead to immune system dysfunctions, including increased susceptibility to fungal infections and certain autoimmune diseases. CARD9 has therefore emerged as a critical target for understanding and potentially treating immune-related disorders and infections.
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Recombinant Caspase Recruitment Domain Family, Member 9 (CARD9) is a recombinant Mouse protein produced in a Prokaryotic expression system (E. coli).
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