CARD9 antibody
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Description
Adapter protein that plays a key role in innate immune response to a number of intracellular pathogens, such as C.albicans and L.monocytogenes. Is at the crossroads of ITAM-tyrosine kinase and the Toll-like receptors(TLR) and NOD2 signaling pathways. Probably controls various innate immune response pathways depending on the intracellular pathogen. In response to L.monocytogenes infection, acts by connecting NOD2 recognition of peptidoglycan to downstream activation of MAP kinases(MAPK) without activating NF-kappa-B. Also involved in activation of myeloid cells via classical ITAM-associated receptors and TLR: required for TLR-mediated activation of MAPK, while it is not required for TLR-induced activation of NF-kappa-B(By similarity). Controls CLEC7A(dectin-1)-mediated myeloid cell activation induced by the yeast cell wall component zymosan, leading to cytokine production and innate anti-fungal immunity: acts by regulating BCL10-MALT1-mediated NF-kappa-B activation pathway. Activates NF-kappa-B via BCL10. In response to the hyphal form of C.albicans, mediates CLEC6A(dectin-2)-induced I-kappa-B kinase ubiquitination, leading to NF-kappa-B activation via interaction with BCL10. In response to fungal infection, may be required for the development and subsequent differentiation of interleukin 17-producing T helper(TH-17) cells.
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | caspase recruitment domain family, member 9 (CARD9) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | WB: 1:500-1:2000 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | 50-59kd |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, WB |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| UniProt ID | Q9H257 |
| Gene ID | 64170 |
| Alias | CARD9, CANDF2,Hcard9,IMD103 |
| Background | Antibody anti-CARD9 |
| Status | RUO |
| Note | Mol. Weight 50-59 kDa |
Descripción
CARD9 is a key protein in the immune response, particularly in the signaling pathways of innate immunity. It is involved in activating the NF-κB signaling pathway, which plays a crucial role in inflammation and immune cell activation. CARD9 acts as an adaptor protein that connects pattern recognition receptors, such as C-type lectin receptors (CLRs), to downstream signaling pathways. This enables the recognition of microbial pathogens and triggers an immune response. Specifically, CARD9 is important in the recognition of fungal and bacterial infections, where it contributes to the activation of inflammatory cytokines and the recruitment of immune cells. Mutations or deficiencies in CARD9 can lead to immune system dysfunctions, including increased susceptibility to fungal infections and certain autoimmune diseases. CARD9 has therefore emerged as a critical target for understanding and potentially treating immune-related disorders and infections.
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