Mouse BTB/POZ Domain-Containing Protein KCTD12 (KCTD12) ELISA Kit
715€ (96 tests)
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name
Mouse BTB/POZ Domain-Containing Protein KCTD12 (KCTD12) ELISA Kit
category
ELISA Kits
provider
Abbexa
reference
abx529513
tested applications
ELISA
Description
Mouse BTB/POZ Domain-Containing Protein KCTD12 (KCTD12) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Mouse BTB/POZ Domain-Containing Protein KCTD12 concentrations in tissue homogenates, cell lysates and other biological fluids.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | ELISA Kits |
| Immunogen Target | BTB/POZ Domain-Containing Protein KCTD12 (KCTD12) |
| Reactivity | Mouse |
| Detection Method | Colorimetric |
| Assay Data | Quantitative |
| Assay Type | Sandwich |
| Test Range | 0.156 ng/ml - 10 ng/ml |
| Sensitivity | < 0.07 ng/ml |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 96 tests |
| Form | Lyophilized |
| Tested Applications | ELISA |
| Sample Type | Tissue homogenates, cell lysates and other biological fluids. |
| Availability | Shipped within 5-15 working days. The validity for this kit is 6 months. |
| Storage | Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| UniProt ID | Q6WVG3 |
| Gene ID | 239217 |
| Alias | KCTD12,PFET1,PFETIN,C13orf2 |
| Background | Elisa kits for KCTD12 |
| Status | RUO |
| Note | Validity: The validity for this kit is 6 months. This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. |
Descripción
KCTD12 is a member of the potassium channel tetramerization domain (KCTD) family and functions as an auxiliary subunit of GABA-B receptors. KCTD12 modulates GABA-B receptor signaling by accelerating activation and desensitization kinetics, fine-tuning inhibitory neurotransmission in the central nervous system. It is predominantly expressed in brain regions involved in cognition, sensory processing, and motor control, where it regulates synaptic inhibition and neuronal excitability. KCTD12 also interacts with various proteins through its BTB/POZ domain, contributing to cellular processes like ubiquitination and transcriptional regulation. Beyond its role in neurotransmission, KCTD12 has been implicated in cancer, particularly gastrointestinal stromal tumors (GISTs), where its expression influences tumor cell proliferation and survival. In psychiatric disorders, such as anxiety and depression, altered KCTD12 expression disrupts GABA-B receptor-mediated signaling, impairing inhibitory balance in neural circuits. Its role as a GABA-B receptor modulator and involvement in protein-protein interactions highlights KCTD12 as a key regulator of neuronal function and a potential therapeutic target for neurological disorders and cancer.
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